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The CRYOSTAT2 trial: The rationale and study protocol for a multi-Centre,randomised, controlled trial evaluating the effects of early high-dose cryoprecipitate in adult patients with major trauma haemorrhage requiring major haemorrhage protocol activation
Authors:Nicola Curry  Ross Davenport  Joanne Lucas  Alison Deary  Jonathan Benger  Antoinette Edwards  Amy Evans  Claire Foley  Laura Green  Stephen Morris  Helen Thomas  Karim Brohi  Simon J. Stanworth
Affiliation:1. Oxford UniversityHospitals NHS Foundation Trust, Nuffield Orthopaedic Hospital, Oxford, UK;2. Centre for Trauma Sciences, Blizard Institute, Queen Mary University of London, London, UK;3. NHS Blood and Transplant Clinical Trials Unit, Cambridge, UK;4. Faculty of Health and Applied Sciences, University of the West of England, Bristol, UK;5. Trauma Audit and Research Network, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford, UK;6. Blizard Institute, Queen Mary University of London, London, UK;7. Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK;8. NHS Blood and Transplant Clinical Trials Unit, Bristol, UK;9. NHS Blood and Transplant and Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK
Abstract:
Keywords:cryoprecipitate  fibrinogen  Haemorrhage  transfusion  trauma
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