支气管哮喘患者血浆中尾加压素Ⅱ的变化及其意义

目的探讨尾加压素Ⅱ（UⅡ）在支气管哮喘发病中的意义。方法采用放射免疫法测定哮喘患者在急性发作期和临床缓解期血浆中UⅡ含量，并常规进行肺功能检测。结果28例哮喘患者在急性发作期和临床缓解期血浆UⅡ含量分别为（1．65±0．31）μg/L及（1．27±0．38）μg/L，二者差异显著（t=4．692，P〈0．01）；急性发作期血浆UⅡ含量随病情恶化而升高，但差异无统计学意义（P〉0．05）；男性与女性之间、吸烟与不吸烟之间血浆uⅡ含量差异无统计学意义（P〉0．05）；哮喘急性发作期血浆UⅡ含量与第1s用力呼气容积（FEV1）占预计值百分比呈负相关（r=-0．325，P〈0．05）。结论哮喘发作时血浆UⅡ含量增加，UⅡ可能参与哮喘的发病。

The changes and significance of plasma leve of urotensin H in asthma bronchial

Objective To investigate the role of urotensin Ⅱ （ U Ⅱ ） in the pathogenesis of asthma. Methods Lung function, level of U Ⅱ in plasma were studied in 28 asthmatic patients in acute exacerbation and in clinical remission. Results Plasma U Ⅱ level from acute asthma was higher than that of remissed asthma（ （ 1.65 ± 0. 31 ） μg/L vs （ 1.27 ± 0. 38 ） μg/L and there is significant difference between them （ P 〈 0. 01 ）. No significant difference of plasma UⅡ levels was found between male and female, smokers and non -smokers （P 〉 0.05 ）. Plasma UⅡ levels of asthma patients in acute exacerbation had a tendency to increase as disease deteriorated, which negatively correlated with FEV1% predicted （ r = - 0. 325, P 〈 0. 05 ）. Conclusion Plasma UⅡ levels increased when asthma attack. UⅡ may be involved in the pathogenesis of asthma.