40岁以下阴茎癌患者的临床特点

目的分析40岁以下阴茎癌患者的临床特点及预后。方法搜集SEER数据库中从2004~2009年收录的1 516例阴茎癌患者的临床资料,将患者分为青年组(40岁)及中老年组(≥40岁),对比分析2组患者的生存率及临床特点。结果 40岁以下阴茎癌患者有65例,占4.3%。在2组中均以白种人多见,分别占80%(40岁)及83.8(≥40岁),组间无统计学差异(P=0.099)。在青年组,已婚者占52.3%,中老年组为57.7%(P=0.67)。本研究中阴茎癌发生部位不明的占大多数,在青年组及中老年组中分别为41.5%(40岁)及47.2%(≥40岁)(P=0.45),其次是龟头(35.4%比32.7%)。青年组的中分化阴茎癌(gradeⅡ)(46.2%)与中老年比(38.7%)较为常见,但是并没有统计学意义(P=0.715)。青年组未见分化较差的癌(gradeⅣ),而中老年组中分化较差的癌(gradeⅣ)占0.69%。对于总生存率,2组未见明显差异(P=0.706)。2组总的中位生存时间青年组为69个月,中老年71个月,差异无统计学意义(P=0.997)。但Ⅲ期中,青年组中位生存期(47个月)明显短于中老年组(71个月)(P=0.032,差异有统计学意义。结论从收集的数据库资料来看,青年组阴茎癌患者的临床病理特征与中老年组相似,总生存率无明显不同,但是在两组中3期阴茎癌患者中位生存期有明显差异。

Clinical characteristics and survival analysis of penile cancer in patients below 40years of age

Objective To investigate the clinical characteristics and survival rate of penile cancer in patients below 40 years of age.Methods Data of 1 516 patients with penile cancer treated during 2004 to 2009 were collected from SEER database and retrospectively analyzed.The patients were divided into the young group （〈40 years） and elderly group （≥ 40 years）.Clinical characteristics and survival rates of the two groups were compared.Results The incidence for patients below 40 years old was 4.3 %.White people were prone to this cancer,accounting for 80 % in the young group and 83.8 % in the elderly group.52.3 % cancers occurred on married persons in the young group and 57.7 % in the elderly group,with no significant difference between the two groups （P=0.67）.The cancer was not clearly located in 41.5% of the young cases and 47.2% of the elderly cases （P=0.45）.35.4% cancers in the young group and 32.7% in the elderly group were located on the glans penis.46.2% cancer in the young group and 38.7% in the elderly group were moderately differentiated （grade Ⅱ）,but there was no difference （P =0.715）.No cancer was diagnosed as grade Ⅳ in the young group,while 0.69 % cancer was diagnosed as grade Ⅳ in the elderly people.The overall survival rates were similar in both groups （P=0.706）.The median survival time was 69 months in young group and 71 months in elderly group （P=0.997）.Subgroup analysis showed that the median survival time of stage Ⅳ penile cancer was shorter in young group than in elderly group （47 months and 71 months,respectively; P=0.032）,which was statistically significant.Conclusions Yong patients with penile cancer present the same clinic-pathologic features as the older ones,and the survival rates of the two groups are similar,while the median survival time of stage Ⅳ penile cancer is shorter in young group than in the elderly group.