肾透明细胞癌淋巴管新生与临床病理因素的关系

目的探讨肾透明细胞癌淋巴管新生与临床病理因素的关系。方法通过免疫组织化学染色方法利用D2-40来标记60例肾透明细胞癌患者标本中的淋巴管,利用光学显微镜测定癌周淋巴管密度(PLVD)并观察癌内淋巴管(ILVs)是否出现,评价PLVD及ILVs与临床病理因素的关系。结果平均PLVD为16.89,按平均值分为两组进行相关性分析表明PLVD与远处转移(P=0.073)、淋巴结转移(P=0.758)、Fuhrman细胞核分级(P=0.866)和肿瘤T分期(P=0.653)无相关性,结果无统计学意义。ILVs的出现与远处转移(P=0.001)、淋巴结转移(P=0.017)及Fuhrman细胞核分级(P=0.002)有相关性,与肿瘤T分期(P=0.570)无相关性。结论 PLVD与临床病理因素包括远处转移、淋巴结转移、Fuhrman细胞核分级及肿瘤T分期无相关性;ILVs的出现与远处转移、淋巴结转移及Fuhrman细胞核分级有显著的相关性。

Correlation between lymphangiogenesis and clinicopathological factors in renal clear cell carcinoma

Objective To explore the correlation between lymphangiogenesis and clinicopathological factors in patients with renal clear cell carcinoma. Methods The D2-40 antibody was used to mark lymphatic vessels of 60 samples of renal clear cell carcinoma with immunohistochemieal staining. Light microscopy was used to determine the peritumoral lymph vessel densi- ty （PLVD） and observe the presence of intratumoral lymphatic vessels （ILVs）. Correlation between the numbers and clinico- pathological factors was assessed. Results Mean PLVD was 16.89, and no significant difference was found between the pa- tients with PLVD below average and those with PLVD above average in terms of distant metastasis （P=0. 073）, lymph node metastasis （P 0. 758）, the Fuhrman nuclear grade （P =0. 866）, tumor stage （P= 0. 653）. A significant correlation was found between the presence of ILVs and distant metastasis （ P=0. 001）, lymph node metastasis （P= 0.017） and the Fuhrman nuclear grade （P= 0. 002）. However, no significant correlation was found between the tumor T stage （P= 0. 570）. Conclusion There is no correlation between PLVD and clinical pathologic factors including distant metastases, lymph node metastasis, tumor T stage and grade of Fuhrman nuclei. ILVs presence is significantly correlated with distant metastasis, lymph node me- tastasis and Fuhrman nucleus classification.