| PI3K/AKT/mTOR信号通路在肾上腺皮质癌组织的表达特点 |
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| 引用本文： | 宿恒川,黄欣,戴军,周文龙,黄宝星,曹万里,沈周俊,孙福康. PI3K/AKT/mTOR信号通路在肾上腺皮质癌组织的表达特点[J]. 现代泌尿外科杂志, 2014, 0(2): 114-117 |
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| 作者姓名： | 宿恒川 黄欣 戴军 周文龙 黄宝星 曹万里 沈周俊 孙福康 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院泌尿外科,上海200025 |
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| 基金项目： | 上海市自然科学基金（No.10411960000）;上海市慈善癌症基金项目 |
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| 摘 要： | 目的分析PI3K/AKT/mTOR信号通路在肾上腺皮质癌组织中的表达特点及其意义。方法选取2008年1月至2012年12月经手术治疗且具有完整临床、病理资料的肾上腺皮质癌标本15例,以正常肾上腺组织(肾癌患者施行手术时所取下)12例作为对照。研究这些组织中该信号通路关键蛋白p-AKT、p-mTOR、p-S6以及血管内皮生长因子(VEGF)的表达情况。结果与对照组比较,p-AKT(12/15,80%)、p-mTOR(11/15,73.3%)、p-S6(13/15,86.7%)以及VEGF(12/15,80%)在肾上腺皮质癌中明显高表达。结论 PI3K/AKT/mTOR信号通路关键蛋白p-AKT、p-mTOR、p-S6以及VEGF参与肾上腺皮质癌的发生发展。
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| 关 键 词： | 肾上腺皮质癌 p-AKT p-mTOR p-S6 VEGF |
Expression of PI3K/AKT/mTOR signaling pathway in adrenocorticai carcinoma |
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| SU Heng-chuan,HUANG jun,SUN Fu-kang. Expression of PI3K/AKT/mTOR signaling pathway in adrenocorticai carcinoma[J]. Journal of MOdern Urology, 2014, 0(2): 114-117 |
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| Authors: | SU Heng-chuan HUANG jun SUN Fu-kang |
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| Affiliation: | . (Department of Urology, 200025,China) Xin, DAI Jun, ZHOU Wen-long, HUANG Bao-xing, CAO Wan-li, SHEN Zhou Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai |
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| Abstract: | Objective To investigate the activity and significance of PI3K/AKT/mTOR signaling pathway in adrenocor- tical carcinoma （ACC）. Methods The clinical data of 15 ACC patients treated during Jan. 2008 and Dec. 2012 were retro- spectively reviewed,with 12 normal adrenal gland （NAG） following nephrectomy for renal tumors serving as controls. The ex- pression of phospho-AKT （p-AKT）, phospho-mTOR （p-mTOR）, phospho-S6 （p-S6） and vascular endothelial growth factor （VEGF） in the diseased adrenal tissues were analyzed by immunohistochemical staining. Results Compared with the control group,the levels of p-AKT （12/15,80%）,p-mTOR（11/15,73.3%）,p-S6 （13/15,86.7%） and VEGF （12/15,80%） were sig- nificantly upregulated in ACC. Conclusion The upregulated PI3K/AKT/mTOR signaling pathway in ACC may participate in the genesis and development of ACC. |
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| Keywords: | adrenocortical carcinoma p-AKT p-mTOR p-S6 VEGF |
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