伴有上尿路梗阻的腺性膀胱炎的病理特征和免疫组化表达

目的探讨伴有上尿路梗阻的腺性膀胱炎的病理特征和免疫组化表达。方法 32例伴有上尿路梗阻与34例不伴有上尿路梗阻腺性膀胱炎的病理切片,光镜观察病理类型,同时采用免疫组化测定p53、Ki67、p21、MMP-9、MUC1、MUC2、COX-2的表达。结果 2组病理类型主要为移行上皮型,其次为肠上皮型,其他类型较少,组间差异无显著性。2组p53、Ki67、p21、MMP-9、MUC1、MUC2、COX-2均有不同程度的阳性表达,组间差异无显著性。泌尿上皮型与混合型相比,COX-2的差异有统计学意义,P0.05。其他不同病理类型腺性膀胱炎之间免疫组化表达的差异无显著性。结论伴有上尿路梗阻的腺性膀胱炎具有不伴有上尿路梗阻的腺性膀胱炎相同的病理特征和免疫组化表达。目前尚难通过免疫组化测定p53、Ki67、p21、MMP-9、MUC1、MUC2、COX-2的表达来预示腺性膀胱炎的癌变趋势。

Pathological features and immunohistochemical expression of cystitis glandularis complicated with upper urinary tract obstruction

Objective To explore the pathological features and immunohistochemical expression of cystitis glandularis complicated with upper urinary tract obstruction. Methods Pathological sections from 32 cases of cystitis glandularis compli- cated with upper urinary tract obstruction and 34 cases of cystitis glandularis without upper urinary tract obstruction were ob- served to detect the pathological features with microscope. Meanwhile, an immunohistochemical analysis was employed to de- termine the expressions of p53, Ki67, p21, MMP-9, MUC1, MUC2 and COX-2. Results In the two groups, the main patho- logic type was transitional epithelial, followed by intestinal epithelial, with a few other types, and the difference between the two groups was not significant. All immunohistochemical expressions of p53, Ki67, p21, MMP-9, MUC1, MUC2 and COX-2 were positive in varying degrees, and there was no significant difference between the groups. When transitional epithelial type was compared with the mixed type, the difference of COX-2 was significant （P〈0.05）. The differences of immunohistochem- ical expressions among other different pathologic types were not significant. Conclusions Glandular cystitis complicated with upper urinary tract obstruction shares the same pathological features and immunohistochemical expression with and without up- per urinary tract obstruction. Therefore, it is hard to predict the malignant tendency of glandular cystitis by the determination of immunohistochemical expressions in tissue.