| 邻近山羊门静脉行高强度聚焦超声消融的病理观察 |
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| 引用本文： | Jiang F,He M,Liu Y,Huang X,Zhang L,Bai J,Wang Z. 邻近山羊门静脉行高强度聚焦超声消融的病理观察[J]. 生物医学工程学杂志, 2011, 28(4): 666-669 |
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| 作者姓名： | Jiang F He M Liu Y Huang X Zhang L Bai J Wang Z |
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| 作者单位： | 重庆医科大学生物医学工程系医学超声研究所; |
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| 基金项目： | 国家自然科学基金重点项目资助(30830040) |
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| 摘 要： | 观察使用磁共振(MRI)导航的高强度聚焦超声(MRgHIFU)消融靠近山羊门静脉的肝组织的病理变化;在MRI监控下,对50只山羊靠近门静脉0、5和10 mm处的肝组织进行热消融。其中40只山羊术后立即处死,另外10只在消融7 d后处死。病理观察显示靶区肝组织完全坏死,治疗后即刻0 mm组门静脉出现胶原纤维肿胀(CS)27/40(67.5%)例,血管壁断裂(VWF)为7/40(17.5%)例;5 mm组门静脉CS为8/40(20%)例,VWF(0/40,0%),两组间CS和VWF发生率差异有显著性(P<0.05);10 mm组未见CS(0/40,0%)和VWF(0/40,0%)。消融后7d,各组门静脉标本在光镜下均未见CS和VWF。以上结果表明,MRgHIFU在距山羊门静脉0~5 mm处消融肝组织可能会造成门静脉的急性损伤,但这种损伤是可逆的。
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| 关 键 词： | 高强度聚焦超声 门静脉 病理观察 |
Pathological observation after MRI guided high intensity focused ultrasound therapy for ablating the liver tissues adjacent to goat portal vein |
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| Jiang Feng,He Min,Liu Yingjiang,Huang Xiu,Zhang Lian,Bai Jin,Wang Zhibiao. Pathological observation after MRI guided high intensity focused ultrasound therapy for ablating the liver tissues adjacent to goat portal vein[J]. Journal of biomedical engineering, 2011, 28(4): 666-669 |
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| Authors: | Jiang Feng He Min Liu Yingjiang Huang Xiu Zhang Lian Bai Jin Wang Zhibiao |
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| Affiliation: | Jiang Feng He Min Liu Yingjiang Huang Xiu Zhang Lian Bai Jin Wang Zhibiao(Institute of Ultrasonic Engineering in Medicine,Chongqing Medical University,Chongqing 400016,China) |
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| Abstract: | The present study was aimed to investigate the pathological changes after magnetic resonance imaging(MRI) guided high intensity focused ultrasound(MRgHIFU) therapy for ablating the liver tissue adjacent to goat portal vein.Fifty goats were involved in this study.Normal liver tissues at 0,5,and 10 mm distance from portal vein,respectively,were ablated with MRgHIFU.Among the 50 tested subjects,40 goats were sacrificed immediately after the operations,and the other 10 were sacrificed 7 days after the procedure... |
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| Keywords: | High intensity focused ultrasound(HIFU) Portal vein Pathological observation |
| 本文献已被 CNKI PubMed 等数据库收录！ |
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