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The mechanism of sevoflurane-induced cardioprotection is independent of the applied ischaemic stimulus in rat trabeculae |
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| Authors: | Bouwman R A van't Hof F N G de Ruijter W van Beek-Harmsen B J Musters R J P de Lange J J Boer C |
| Affiliation: | 1 Department of Anesthesiology, VU University Medical Center (VUmc)-Institute for Cardiovascular Research Vrije Universiteit (ICaR-VU) De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands 2 Laboratory for Physiology, VU University Medical Center (VUmc)-Institute for Cardiovascular Research Vrije Universiteit (ICaR-VU) van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands 3 Abbott B.V. Siriusdreef 51, NL-2131 WT Hoofddorp The Netherlands |
| Abstract: | Background. Sevoflurane protects the myocardium against ischaemicinjury through protein kinase C (PKC) activation, mitochondrial |
| Keywords: | anaesthetics volatile, sevoflurane complications, hypoxia heart, myocardial preservation metabolism, free radicals metabolism, second messengers |
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