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CD146与Ki67在葡萄胎组织中的表达及临床意义
引用本文:徐本群,周琼,邢益祥,陈翀.CD146与Ki67在葡萄胎组织中的表达及临床意义[J].中国医药科学,2012(17):29-31.
作者姓名:徐本群  周琼  邢益祥  陈翀
作者单位:安徽省肥西县人民医院妇产科;艾迪康医学检验中心;合肥市病理学实验室;徐州医学院附属医院内科
基金项目:国家自然科学基金青年科学基金(81000210)
摘    要:目的检测CD146与Ki67在葡萄胎病变组织中的表达,以评估其临床意义。方法采用免疫组化SP法检测36例HM(完全性葡萄胎21例,部分性葡萄胎15例)与阴性对照组(正常人工流产组织18例)组织中CD146与Ki67的表达情况,并进行术后随访、观察预后。结果与正常人工流产组织比较,CD146与Ki67在HM组织中呈高表达,差异有统计学意义(P<0.05);CD146在完全性HM病变组织中度阳性的表达率为95%(20/21),在部分性HM病变组织中为13%(2/15);Ki67在完全性HM病变组织中度阳性的表达率为90%(19/21),在部分性HM病变组织中为7%(1/15),提示CD146与Ki67在完全性HM中的表达强度较部分性HM明显增高,差异有统计学意义(P<0.05)。结论 CD146与Ki67可以作为辅助鉴别HM病理分类、指导HM治疗及预后评估的标志物。

关 键 词:葡萄胎  免疫组化  CD146  Ki67

Expression and clinical significance of CD146 and Ki67 in diagnosis of hydatidiform mole
XU Benqun,ZHOU Qiong,XING Yixiang,CHEN Chong.Expression and clinical significance of CD146 and Ki67 in diagnosis of hydatidiform mole[J].China Medicine and Pharmacy,2012(17):29-31.
Authors:XU Benqun  ZHOU Qiong  XING Yixiang  CHEN Chong
Institution:1.Department of Obstetrics and Gynecology,the People’s Hospital of Feixi County,Feixi 231200,China;2.Adicon Clinical Laboratories.Inc.,Hefei 230022,China;3.Pathological Laboratory of Hefei City,Hefei 230022,China;4.Department of Internal Medicine,the Affiliated Hospital of Xuzhou Medical College,Xuzhou 221002,China
Abstract:Objective To examine the expression of CD146 and Ki67 in the hydatidiform mole tissue and to examine the value.Methods 36 hydatidiform moles,including 21 complete hydatidiform moles and 15 partial hydatidiform moles,were evaluated by immunohistochemical SP method,so was the negative control group,the normal abortion organizations.Postoperative follow-up survey and prognosis observation were also carried out.Results The CD146 and Ki67 immunoactivity was significantly higher in the HM tissues than that in the normal abortion organizations(P < 0.05).The positive rate of the moderate expression of CD146 was 95%(20/21) in complete HM tissues,and 13%(2/15) in partial HM tissues.Ki67,on the other hand,was found moderately expressed in 90%(19/21) of the complete HM tissues,and in 7%(1/15) of partial HM tissues.So it is shown that the expression density of CD146 and Ki67 is significantly higher in complete HM tissues than that in partial HM tissues(P < 0.05).Conclusion CD146 and Ki67 can be helpful in studying the pathological classification,guiding treatment,and predicting prognosis of hydatidiform mole.
Keywords:Hydratidiform mole  Immunohistochemistry  CD146  Ki67
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