蛇毒血凝酶在腹部手术中止血作用的系统评价

目的评价蛇毒血凝酶在腹部手术中止血作用的有效性和安全性。方法采用RCT法或采用盲法进行分析。研究对象均为腹部手术患者,术后全部进行随访。分为血凝酶组和对照组。测量术中切口出血量、术中切口单位面积出血量、术后凝血酶原时间。对纳入研究的结果采用RevMan4.2.10软件进行Meta分析。结果经筛选最终纳入3篇RCT进行分析,共340例腹部手术患者。Meta分析显示:血凝酶组与对照组相比,在术中出血量和术中单位面积出血量的差异有统计学意义,两组术后凝血酶原时间比较差异无统计学意义。结论腹部手术中应用蛇毒血凝酶是有效安全的。

A systematic review of the efficacy and safety of hemocoagulase in abdominal operation surgery

Objective To assess the efficacy and safety of hemocoagulase in abdominal operation surgery.Methods RCT method or blinded analysis was used.The subjects were the patients with abdominal surgery,and all were followed-up postoperative.They were divided into hemocoagulase group and control group.The amount of intraoperative wound bleeding,intraoperative incision per unit area of bleeding,postoperative prothrombin time were measured.The results were analyzed by RevMan 4.2.10 software.Results 3 trials never reported blind method and not described random allocation concealment method.Statistical differences were found in the hemorrhagic and hemorrhagic volume per square unit,no statistical differences were found in PT for two groups.Conclusion Hemocoagulase is effective in preventing and treating bleeding during abdominal operation and without PT complication.