老年冠心病患者血浆同型半胱氨酸和C-反应蛋白水平的变化及临床意义

目的：探讨老年冠心病患者血浆同型半胱氨酸（Hcy）和C-反应蛋白（CRP）水平变化，阐明老年冠心病患者发病的危险因素。方法：将90例老年冠心病患者分为稳定型心绞痛（SAP）组30例、不稳定型心绞痛（UAP）组30例及急性心肌梗死（AMI）组30例。同时选择60岁以上体检健康的老年人30例为对照组。所有研究对象空腹采血后分离血浆，检测血浆Hcy和CRP。结果：老年冠心病各组TC和TG均高于对照组（P<0.05），TG升高呈AMI组＞UAP组＞SAP组趋势。老年冠心病各组血浆Hcy和CRP水平均高于对照组（P<0.05），老年冠心病各组之间血浆Hcy和CRP水平比较差异仍有显著性（P<0.05），呈AMI组＞UAP组＞SAP组趋势。结论：老年冠心病与Hcy和CRP水平升高有关，高同型半胱氨基(HHcy)血症和CRP水平升高可能是老年冠心病发病的一个危险因素。同时，血脂异常与HHcy血症和CRP水平升高有关联。随着老年冠心病严重程度的增加，血浆Hcy和CRP水平也增高，可以通过监测血浆Hcy和CRP水平增高程度来预测老年冠心病病变的严重程度。

Changes of homocysteic acid and C-reactive protein levels in blood plasma of elderly patients with coronary heart disease and their clinical significances

Objective To investigate the changes of homocysteic acid (Hcy) and C-reactive protein (CRP) levels in blood plasma of elderly patients with coronary heart disease and elucidate the risk factors of elderly patients with coronary heart disease.Methods 90 elderly patients with coronary heart disease were divided into 3 groups:stable angina pectoris group (SAP)(n=30),unstable angina pectoris group(UAP)(n=30),acute myocardial infarction group(AMI)(n=30).30 healthy elderly persons elder than 60 years old were enr...