| 慈桃软坚胶囊抑制小鼠Lewis肺癌血管生成作用实验研究 |
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| 引用本文： | 贾学科,胡立新,刘建国,闫萍,王志刚. 慈桃软坚胶囊抑制小鼠Lewis肺癌血管生成作用实验研究[J]. 现代预防医学, 2011, 38(7): 1307-1309 |
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| 作者姓名： | 贾学科 胡立新 刘建国 闫萍 王志刚 |
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| 作者单位： | 1. 河北省保定恒兴医院河北省中西医结合肿瘤治疗中心,保定,071051
2. 河北人学附属医院中西医结合科 |
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| 基金项目： | 河北省中医药管理局科学技术研究计划课题 |
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| 摘 要： | [目的]探讨慈桃软坚胶囊对小鼠Lewis肺癌血管生成的抑制作用。[方法]构建小鼠Lewis肺癌模型,随机分3组,分别为对照组(A组),慈桃软坚胶囊组(B组)及吉西他滨组(C组)。利用彩色多谱勒超声观察血流动力学、免疫组化技术检测肿瘤微血管密度(MVD)及巨噬细胞等观察和比较两组的肿瘤血管生成情况。[结果]与对照组比较,彩色超声多谱勒显示慈桃软坚胶囊和吉西他滨组肿瘤血管数量减少,差异有统计学意义(P﹤0.05)。肿瘤微血管密度和巨噬细胞免疫组化结果显示慈桃软坚胶囊和吉西他滨组与对照组比较差异有统计学意义(P﹤0.05)。慈桃软坚胶囊和吉西他滨组两组比较差异无统计学意义(P﹥0.05)。[结论]慈桃软坚胶囊有抑制肺癌肿瘤血管生成的作用。
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| 关 键 词： | 慈桃软坚胶囊 吉西他滨 肿瘤血管生成 Lewis肺癌 |
STUDY ON INHIBITION EFFECTS OF CHI TAO RUAN JIAN CAPSULE ON ANGIOGENESIS OF LEWIS LUNG CANCER OF MICE |
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| JIA Xue-ke,HU Li-xin,LIU Jian-guo,et al.. STUDY ON INHIBITION EFFECTS OF CHI TAO RUAN JIAN CAPSULE ON ANGIOGENESIS OF LEWIS LUNG CANCER OF MICE[J]. Modern Preventive Medicine, 2011, 38(7): 1307-1309 |
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| Authors: | JIA Xue-ke HU Li-xin LIU Jian-guo et al. |
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| Affiliation: | JIA Xue-ke,HU Li-xin,LIU Jian-guo,et al.(Cancer Treatment Center of Integrative Medicine,Hengxing Hospital in Baoding,Baoding 071051,China) |
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| Abstract: | [Objective]To investigate the inhibition effect of Chi Tao Ruan Jian capsule on angiogenesis of Lewis lung cancer in mice.[Methods]Murine Lewis lung cancer model was constructed,then were randomly divided into three groups,namely the control group(A group),Chi Tao Ruan Jian capsule group(B group)and gemcitabine group(C group).Used color Doppler ultrasound hemodynamic and immunohistochemical to detect tumor microvessel density(MVD)and observe macrophages,compared the tumor angiogenesis in two groups.[Results... |
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| Keywords: | Chi Tao Ruan Jian capsule Gemcitabine Tumor angiogenesis Lewis lung cancer |
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