| Ad-siICOS阻断ICOS共刺激通路抑制大鼠角膜移植排斥反应的实验研究 |
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| 引用本文： | 袁伟,陆晓和,宫玉波,周瑾. Ad-siICOS阻断ICOS共刺激通路抑制大鼠角膜移植排斥反应的实验研究[J]. 眼科, 2011, 20(3): 161-164 |
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| 作者姓名： | 袁伟 陆晓和 宫玉波 周瑾 |
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| 作者单位： | 1. 济南军区青岛第一疗养院体检科,266071
2. 南方医科大学珠江医院眼科 |
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| 摘 要： | 目的 观察携带报告基因GFP且表达ICOS-siRNA的重组腺病毒(Ad-siICOS-EGFP)阻断可诱导共刺激分子(inducible costimulator,ICOS)共刺激通路对角膜移植急性免疫排斥的抑制作用.设计实验性研究.研究对象Wistar大鼠(供体)及SD(受体)大鼠.方法 取Wistar大鼠(供体)...
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| 关 键 词： | 角膜移植 RNA干扰 可诱导共刺激分子 |
The effect of blockade ICOS co-stimulator pathway with Ad-siICOS on cornea transplantation immunology |
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| YUAN Wei,LU Xiao-he,GONG Yu-bo,ZHOU Jin. The effect of blockade ICOS co-stimulator pathway with Ad-siICOS on cornea transplantation immunology[J]. Ophthalmology in China, 2011, 20(3): 161-164 |
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| Authors: | YUAN Wei LU Xiao-he GONG Yu-bo ZHOU Jin |
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| Affiliation: | YUAN Wei,LU Xiao-he,GONG Yu-bo,ZHOU Jin.Department of Physical Examination,Qingdao First Sanitarium of Jinan Military,Qingdao 266071,Shandong Province,China |
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| Abstract: | Objective To observe the inhibitory action of Ad-siICOS-EGFP to the cornea transplantation acute immunological rejection with the co-stimulator passageway blockade.Design Experimental study.Participants Wistar rat and SD rat.Methods Build homogeneity penetrability corneal transplantation rat model with Wistar rat(donor) and SD(acceptor) rat.Divide the SD rats into four group with 20 rats in each group: penetrability corneal transplantation group as the control group(group A);Ad-siICOS-EGFP injection group(g... |
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| Keywords: | Cornea transplantation RNA interference inducible costimulator |
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