早产儿胰岛素样生长因子-1和胰岛素样生长因子结合蛋白-3早期检测的临床意义

目的:研究早产儿早期胰岛素样生长因子-1(IGF-1)和胰岛素样生长因子结合蛋白-3(IGFBP-3)水平,指导围产期临床孕产妇及早产儿合理营养干预。方法:对145例早产儿生后3天内进行IGF-1I、GFBP-3测定,将其按小于胎龄儿与适于胎龄儿、小早产儿(小于34周)与晚期早产儿(大于34周)、双胞胎大体重与小体重3种方式对比分组,分别比较IGF-1I、GFBP-3水平。结果:145例早产儿生后3天内监测IGF-1I、GFBP-3值显示适于胎龄儿组明显高于小于胎适龄儿组,大于34周组明显高于小于34周组,大体重组明显高于小体重组,组间比较有极显著性差异(P<0.01)。结论:应加强围生期孕产妇管理,避免早产和胎儿宫内发育迟缓发生,早产儿、小于胎龄儿生后应尽早给予合理营养支持。

The Clinical Significance to the Early Detection of the Level of the IGF-1 and IGFBP-3 to the Premature Infants

Objective：To research the level of the IGF-1 and IGFBP-3 to the premature infants and guide the rational nutrition of the puerpera and premature infants in perinatal period.Methods：The level of the IGF-1 and IGFBP-3 to the one hundred and forty five premature infants were determined in three days after birth meanwhile we divided them into three groups included small for gestation age infants（SGA） and appropriate for gestational age infants（AGA）、little premature infants（less than thirty four weeks） and later premature infants（more than thirty four weeks）、big and little weight of the twins,then compared the level of the IGF-1 and IGFBP-3 to each other.Results：To determiind the level of the IGF-1 and IGFBP-3 to the the one hundred and forty five premature infants in three days after birth we found that the level of them in AGA,more than thirty four weeks and big weight groups were higher than the SGA,less than thirty four weeks and little weight groups＇.The group comparison was significant difference（P0.01）.Conclusion：We should strengthen the rational nutrition of the puerpera in perinatal period and avoid the occurrence of the prematurity and intrauterine growth retardation.Meanwhile the premature and small for gestation age infants were gave the rational nutrition as early as possible.