实时三维超声心动图评价正常儿童右心室整体及局部容积和收缩功能

目的 应用实时三维超声心动图(RT-3DE)评价不同年龄正常儿童右室整体及局部容积和收缩功能.方法 192例正常儿童按年龄分为5组:Ⅰ组,＜1岁,32例;Ⅱ组,≥1岁-＜3岁,46例;Ⅲ组,≥3岁-＜6岁,36例;Ⅳ组,≥6岁-＜9岁,41例;Ⅴ组,≥9岁-＜14岁,37例.应用RT-3DE于心尖偏胸骨旁四腔心采集右室全容积声像图,使用TomTec RV-Function软件分析右室整体和局部(包括流入道、流出道、心尖肌小梁部)舒张末期容积(EDV)、收缩末期容积(ESV)及射血分数(EF),计算各局部EDV占右室EDV的比率,对右室三局部容积和收缩功能进行相互比较,并对各年龄组右室整体及局部EF和各局部所占右室容积比率进行相互比较;同时对右室整体和局部EDV与年龄及体格指标进行相关性和曲线估计回归分析.结果 在右室三局部容积和收缩功能的相互比较中:右室流入道EDV及EF均大于流出道、心尖肌小梁部(P＜0.05),流出道EDV与心尖肌小梁部差异无统计学意义(P＞0.05),但流出道EF大于心尖肌小梁部(P＜0.05);各年龄组间右室整体及局部EF差异无统计学意义(P＞0.12);三局部所占右室容积比率在各年龄组间差异无统计学意义(P＞0.58).右室整体及局部EDV与年龄、身高、体质量、体表面积(BSA)呈显著正相关(r＞0.77,P=0.000),其中与体表面积的相关性最显著(r＞0.83,P=0.000),曲线估计分析表明右室整体及局部EDV与各体格指标之间的回归模型以幂模型最佳,其中与体表面积建立的回归模型最佳.结论 在右室三局部中,右室流入道和流出道的容积和收缩功能是右室泵血功能的重要组成部分,右室容积的增长在儿童时期并非随年龄体格指标呈线性增长,而以指数模式增长.

Abstract：

Objective To evaluate right ventricular(RV) global and regional volume and systolic function by real-time three-dimensional echocardiography (RT-3DE) in normal children with different age.Methods One hundred and ninty-two normal children were divided into five groups by age:group Ⅰ,＜1 years old,32 cases;group Ⅱ,≥1 years old-＜3 years old,46 cases;group Ⅲ,≥3 years old-＜6 years old,36 cases;group Ⅳ,≥6 years old-＜9 years old,41 cases;group Ⅴ,≥9 years old-＜14 years old,37 cases.Full volume imaging of RV was obtained at the parasternal four-chamber view near the apex by RT-3DE.RT-3DE data set were analyzed off-line by TomTec RV-Function.RV were divided into three parts:inflow,body,outflow.The measurements were including RV global and regional end-diastolic volume (EDV),end-systolic volume (ESV),ejection fraction (EF) and the ratio of regional parts EDV to RVEDV. The volume and systolic function were compared in three regional parts.RV global and regional parts EF and the ratio of regional parts EDV to RVEDV were also compared in five age groups.Correlation analysis and curve estimation were studied on RV global and regional EDV with age and physical development indexes.Results In the comparison of three regional parts:inflow EDV and EF were higher than outflow and body parts (P＜0.05).No significant different was found between outflow EDV and body EDV (P＞0.05),however,outflow EF was significant higher than body EF(P＜0.05).The comparison of RV global and regional EF in five age groups were no statistical different (P＞0.12). The ratio of regional parts EDV to RVEDV remained constant in five age groups(P＞0.58).Correlation analysis showed the global and regional RV volume were strongly correlated with age,height,weight and BSA (r＞0.77,P=0.000).The best correlation was found with BSA (r＞0.83,P=0.000).Curve estimation demonstrated that the relationship of RV global and regional EDV with age and physical development indexes could be best expressed by power model,the best matched model were found with BSA.Conclusions Among three regional parts of RV,inflow and outflow parts volume contraction were the two main contribution factors for RV function.In childhood RV volume didn't increase linearly with age and physical development indexes,but in an exponential model.

Evaluation of right ventricular global and regional volume and systolic function in normal children by real-time three-dimensional echocardiography

Objective To evaluate right ventricular(RV) global and regional volume and systolic function by real-time three-dimensional echocardiography (RT-3DE) in normal children with different age.Methods One hundred and ninty-two normal children were divided into five groups by age:group Ⅰ,＜1 years old,32 cases;group Ⅱ,≥1 years old-＜3 years old,46 cases;group Ⅲ,≥3 years old-＜6 years old,36 cases;group Ⅳ,≥6 years old-＜9 years old,41 cases;group Ⅴ,≥9 years old-＜14 years old,37 cases.Full volume imaging of RV was obtained at the parasternal four-chamber view near the apex by RT-3DE.RT-3DE data set were analyzed off-line by TomTec RV-Function.RV were divided into three parts:inflow,body,outflow.The measurements were including RV global and regional end-diastolic volume (EDV),end-systolic volume (ESV),ejection fraction (EF) and the ratio of regional parts EDV to RVEDV. The volume and systolic function were compared in three regional parts.RV global and regional parts EF and the ratio of regional parts EDV to RVEDV were also compared in five age groups.Correlation analysis and curve estimation were studied on RV global and regional EDV with age and physical development indexes.Results In the comparison of three regional parts:inflow EDV and EF were higher than outflow and body parts (P＜0.05).No significant different was found between outflow EDV and body EDV (P＞0.05),however,outflow EF was significant higher than body EF(P＜0.05).The comparison of RV global and regional EF in five age groups were no statistical different (P＞0.12). The ratio of regional parts EDV to RVEDV remained constant in five age groups(P＞0.58).Correlation analysis showed the global and regional RV volume were strongly correlated with age,height,weight and BSA (r＞0.77,P=0.000).The best correlation was found with BSA (r＞0.83,P=0.000).Curve estimation demonstrated that the relationship of RV global and regional EDV with age and physical development indexes could be best expressed by power model,the best matched model were found with BSA.Conclusions Among three regional parts of RV,inflow and outflow parts volume contraction were the two main contribution factors for RV function.In childhood RV volume didn't increase linearly with age and physical development indexes,but in an exponential model.