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| 大鼠松果体褪黑素含量增龄性变化的研究 | |
| 引用本文： | 朱俊德,王景传,许庭良,龚明.大鼠松果体褪黑素含量增龄性变化的研究[J].解剖学研究,2006,28(1):26-29. |
| 作者姓名： | 朱俊德 王景传 许庭良 龚明 |
| 作者单位： | 1. 贵阳医学院解剖学教研室,贵阳,55004 2. 贵阳医学院组织胚胎学教研室,贵阳,55004 3. 贵州益佰制药有限公司药研所,贵阳,55002 |
| 基金项目： | 贵阳医学院校科研和教改项目 |
| 摘 要： | 目的探讨大鼠松果体褪黑素含量的增龄性变化规律。方法32只健康SD大鼠随机分为1～2月龄组、4～5月龄组、11～12月龄组和≥24月龄组4个年龄组。每组8只,雌雄各半。用高效液相色谱测定松果体褪黑素含量。结果1～2月龄组褪黑素含量为1.492±0.158,4～5月龄组为1.088±0.059,11～12月龄组为0.233±0.101,≥24月龄组为0.127±0.037,各组间差异有统计学意义(P<0.01)。结论大鼠松果体随增龄而出现褪黑素含量下降,这可能是导致机体发生衰老的原因之一。 |
| 关 键 词： | 松果体 褪黑素 增龄性变化 大鼠 |
| 收稿时间： | 2005-07-20 |
| 修稿时间： | 2005年7月20日 |
A study on the melatonin content of the pineal gland of rats associated with increasing age |
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| ZHU Jun-de,WANG Jing-chuan,XU Ting-liang,GONG Ming.A study on the melatonin content of the pineal gland of rats associated with increasing age[J].Anatomy Research,2006,28(1):26-29. | |
| Authors: | ZHU Jun-de WANG Jing-chuan XU Ting-liang GONG Ming |
| Abstract: | ObjectiveTo explore the change of melatonin content of the pineal gland with aging in rats. MethodsThirty-two healthy Sprague-Dawley rats were randomly divided into four groups: 1～2 months group, 4～5 months group, 11～12 months group and above 24 months group. There were 8 rats in every group, and the number of male and that of female rats are equal. The melatonin content of the pineal gland was determined by the high-performance liquid chromatography. ResultsThe melatonin content of pineal gland in every group was as following: 1～2 months group was 1.492±0.158, 4～5 months group was 1.088±0.059, 11～12 months group was 0.233±0.101, and above 24 months group was 0.127±0.037. There were statistical significance between each group. ConclusionThe melatonin content decreases with aging. The functional changes of pineal gland would be a cause of aging. |
| Keywords: | Pineal gland Melatonin Aging Rats |
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