Alcohol Actions on GABAA Receptors: From Protein Structure to Mouse Behavior |
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| Authors: | Susumu Ueno R. Adron Harris Robert O. Messing A. M. Sanchez-Perez C. W. Hodge T. McMahon D. Wang K. K. Mehmert S. P. Kelley A. Haywood M. F. Olive Kari J. Buck Heather M. Hood Yuri Blednov Geoffrey Findlay Maria Paola Mascia |
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| Affiliation: | Waggoner Center for Alcohol and Addiction Research (RAH, YB, GF, MPM), University of Texas at Austin, Austin, Texas;the Department of Pharmacology (SU), University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan;Ernest Gallo Clinic and Research Center (ROM, AMS-P, CWH, TM, DW, KKM, SPK, AY, MFO), Emeryville, California;and Department of Behavioral Neuroscience and Portland Alcohol Research Center (KJB, HMH), Oregon Health Sciences University and Department of Veterans Affairs Medical Center, Portland, Oregon. |
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| Abstract: | This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were R. Adron Harris and Susumu Ueno. The presentations were (1) Protein kinase Cɛ-regulated sensitivity of γ-aminobutyric acid type A (GABAA) receptors to allosteric agonists, by Robert O. Messing, A. M. Sanchez-Perez, C. W. Hodge, T. McMahon, D. Wang, K. K. Mehmert, S. P. Kelley, A. Haywood, and M. F. Olive; (2) Genetic and functional analysis of a GABAA receptor γ2 subunit variant: A candidate for quantitative trait loci involved in alcohol sensitivity and withdrawal, by Kari J. Buck and Heather M. Hood; (3) Tryptophan-scanning mutagenesis in GABAA receptor subunits: Channel gating and alcohol actions, by Susumu Ueno; and (4) Can a single binding site account for actions of alcohols on GABAA and glycine receptors? by R. Adron Harris, Yuri Blednov, Geoffrey Findlay, and Maria Paola Mascia. |
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| Keywords: | GABAA Protein Kinase C Alcohol Withdrawal Glycine Receptors Quantitative Trait Locus |
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