C77G mutation in protein tyrosine phosphatase CD45 gene and autoimmune hepatitis. |
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Authors: | Fatemehsadat Esteghamat Babak Noorinayer Mohammad Hossein Sanati Azita Hekmatdoost Maryam Zafarghandi Hamid Mohaghegh Shalmani Mohammadreza Agah Mohammad Reza Zali |
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Affiliation: | Research Center for Gastroenterology and Liver Disease, 7th floor, Taleghani Hospital, Tabnak St., Evin, P.O. Box 19835-178, Tehran, Iran; Khatam University, Tehran, Iran. |
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Abstract: | Autoimmune hepatitis (AIH) is a rare frequent, multiplex disorder with undefined etiology. Susceptibility to autoimmune hepatitis results from complex interactions between genetic and environmental factors. In this study, we investigated the involvement of C77G mutation in CD45 gene in patients with autoimmune hepatitis among Iranian population by genotyping this mutation in 70 patients and 140 healthy individuals. METHODS:: After amplifying exon 4 by Polymerase chain reaction, we genotyped this mutation with MspI restriction endonuclease among the studied population. RESULTS:: None of the cases with AIH was hetero or homozygote for C77G mutation. Controls had normal genotype except one of them who was heterozygote for C77G mutation. CONCLUSION:: Our results do not confirm the genetic link between C77G mutation and autoimmune hepatitis in Iranian population. |
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Keywords: | Autoimmune hepatitis CD45 C77G mutation |
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