| 3-噻吩甲氧基乙酸-2-二烷氨基乙酯盐酸盐的合成及对小鼠学习记忆能力的影响 |
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| 引用本文： | 吕晚香,姜京爱,李明洙,Lü Wan-xiang,JIANG Jing-ai,LI Ming-zhu. 3-噻吩甲氧基乙酸-2-二烷氨基乙酯盐酸盐的合成及对小鼠学习记忆能力的影响[J]. 延边医学院学报, 2006, 29(4): 261-263 |
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| 作者姓名： | 吕晚香 姜京爱 李明洙 Lü Wan-xiang JIANG Jing-ai LI Ming-zhu |
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| 作者单位： | [1]延边大学药学院有机化学教研室,吉林延吉133000 [2]延边大学药学院药物化学教研室,吉林延吉133000 |
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| 摘 要： | [目的]合成3-噻吩甲氧基乙酸-2-二烷氨基乙酯盐酸盐,探讨其对小鼠学习记忆能力的影响.[方法]以3-甲基噻吩为原料,经过Whol-Ziegler反应、Williamson反应及酯化反应等合成得到3-噻吩甲氧基乙酸-2-二烷氨基乙酯盐酸盐.采用一次性被动回避反应检测所合成的化合物对小鼠学习记忆能力的影响.[结果]3-噻吩甲氧基乙酸-2-烷氨基乙酯盐酸盐具有促进小鼠学习记忆能力的作用.
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| 关 键 词： | 乙酸乙酯 学习 记忆 小鼠 |
| 文章编号： | 1000-1824(2006)04-0261-02 |
| 收稿时间： | 2006-06-24 |
| 修稿时间： | 2006-06-24 |
Synthesis of 2-dialkylamino ethyl-[(3-thiophenyl)methoxy] acetate hydrochloride and the effects on learning and memory in mice |
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| JIANG Jing-ai,LI Ming-zhu. Synthesis of 2-dialkylamino ethyl-[(3-thiophenyl)methoxy] acetate hydrochloride and the effects on learning and memory in mice[J]. Journal of Medical Science Yanbian University, 2006, 29(4): 261-263 |
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| Authors: | JIANG Jing-ai LI Ming-zhu |
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| Abstract: | OBJECTIVE To synthesis the 2-(dialkylamino)ethyl 2-((thiophen-3-yl)methoxy) acetate(hydrochloride) and to study the effects on learning and memory in mice.METHODS The compounds were(prepared) using 3-methylthiophene,through Whol-Ziegler reaction,and Williamson reaction and esterification.Learning and memory facilitation in mice were studied by one trial passive avoidance response.RESULTS (2-dialkylamino) ethyl-[(3-thiophenyl)methoxy] acetate(hydrochloride) has learning and memory facilitation in mice. |
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| Keywords: | ethyl acetate learning memory mice |
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