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目的观察原发性高血压患儿血浆中硫化氢(H2S)与同型半胱氨酸(Hcy)代谢间的关系,探讨其在高血压发病中的病理生理学意义。方法北京大学第一医院儿科等单位于2005-02随机选取体检时高血压儿童(高血压组)25例,血压正常儿童30例(对照组),对其血压进行测量及体格检查,对家族史进行调查。利用荧光偏振免疫法检测血浆Hcy浓度,应用敏感硫电极法测定血浆H2S浓度。结果高血压组儿童血浆Hcy为(12·68±9·69)μmol/L,对照组儿童血浆Hcy为(6·62±4·79)μmol/L,差别有显著性意义(P<0·01);高血压组血浆H2S为(51·93±6·01)μmol/L,对照组儿童血浆H2S为(65·70±5·50)μmol/L,差别有显著性意义(P<0·01)。将血浆Hcy与H2S浓度做直线相关分析,结果呈负相关(r=-0·379,P<0·05)。将收缩压与H2S/Hcy比值作直线相关分析,结果二者呈明显负相关(r=-0·687,P<0·05)。结论原发性高血压儿童存在硫化氢与H2S代谢失衡。

A metabolic imbalance of hydrogen sulfide and homocysteine in essential hypertensive children

?? AbstractObjectiveTo probe into the metabolic imbalance status of hydrogen sulfide (H2S) and homocysteine (Hcy) in children with essential hypertension,and its significance in the pathogenesis of essential hypertension. MethodsTwenty??five children with essential hypertension and 30 healthy children with normal blood pressure were included in the study.Medical history was investigated and physical examination was conducted for the subjects.Plasma H2S level was detected by modified method with sulfide electrode.Plasma Hcy content was examined by FPIA. ResultsPlasma Hcy levels were (12.68??9.69)??mol/L in hypertensive cases and (6.62??4.79)??mol/L in normal subjects (P<0.01).Plasma H2S levels were (51.93??6.01)??mol/L in hypertensive cases and (65.70??5.50)??mol/L in normal subjects (P<0.01).A negative correlation existed between plasma Hcy and H2S concentrations (r=-0.379,P<0.05).And a negative correlation existed between systolic pressure and plasma H2S /Hcy ratio (r=-0.687,P<0.05). ConclusionThere is a metabolic imbalance of hydrogen sulfide and homocysteine in essential hypertensive children.