普米克令舒、万托林联合甲强龙辅助治疗小儿毛细支气管炎的临床研究

目的：观察普米克令舒、万托林、甲基强的松龙(简称甲强龙)联合辅助治疗小儿重症毛细支气管炎的临床疗效，并对其安全性作出客观评价。方法对120例合川区人民医院诊治的毛细支气管炎患儿进行分组，根据随机数字表法分成观察组(n=80)和对照组(n=40)；其中观察组又分为观察1组与观察2组，各40例。患者入院时均同意接受常规治疗，观察1组另加用普米克令舒、万托林联合治疗；观察2组另加用普米克令舒、万托林、甲强龙联合治疗；对3组患儿治疗有效率及安全性进行观察并记录，主要指标包括咳嗽、喘憋、肺湿啰音、哮鸣音消失时间、住院时间及不良反应等。结果经治疗患儿病情基本得到控制，观察组总体效果显著优于对照组(P <0.01)；观察1组与观察2组之间治疗有效率及咳嗽消失时间比较，差异无统计学意义(P >0.05)，但其他观察指标比较，观察2组效果更佳(P <0.01)。结论普米克令舒、万托林、甲强龙联合治疗小儿重症毛细支气管炎效果显著，安全性好，与常规治疗比较，可显著缩短住院时间、咳嗽及肺湿啰音消失时间等，可提高临床治疗效果，具有临床推广价值。

Clinical study on ventolin and pulmicort respules combined with methylprednisolone in treatment of infantile bronchiolitis

Objective To analyze clinical therapeutic effect of ventolin and pulmicort respules,combined with methylpred-nisolone in treatment of children with bronchiolitis,and make an objective evaluation on their safety.Methods Totally 120 cases of children with bronchiolitis were selected in our hospital,according to the random number table method,the cases were divided into the observation group(n=80)and control group(n = 40);the observation group was divided into the first group and the second group,with 40 cases in each group.All patients agreed to accept the different treatments,observe first groups plus pulmicort and ventolin combined therapy;observation of the second groups plus pulmicort and ventolin and methylprednisolone treatment;they were observed and recorded for the three group,the effective rate of the treatment and safety observation index mainly includes the time of disappearance of cough,wheeze rale disappearance time,pulmonary rales,wheeze disappeared time and hospitalization time, adverse reaction.Results After the treatment,the patient basically under control,obvious effect in the observation group was sig-nificantly better than the control group(P <0.01);in addition,the first groups and the second groups was observed and the effective rate of the treatment of cough disappeared time has no difference(P >0.05),control effect of the second observe group was better than the first group(P <0.01).Conclusion The clinical use of pulmicort and ventolin,methylprednisolone combined treatment of children with severe bronchiolitis significant effect,good safety,compared with conventional treatment,can significantly shorten the time of hospitalization,cough disappeared time,pulmonary rales disappearance time,could improve the clinical efficiency,suitable for use in pediatric treatment,it is worthy of clinical value.