| Annexin A1在甲状腺乳头状癌中的表达及临床意义 |
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| 引用本文： | 钟雪梅,陈敏,邓世山,谢少利.Annexin A1在甲状腺乳头状癌中的表达及临床意义[J].重庆医学,2015(25):3488-3490. |
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| 作者姓名： | 钟雪梅 陈敏 邓世山 谢少利 |
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| 作者单位： | 1. 川北医学院 附属医院内分泌科,四川南充,637000;2. 川北医学院 解剖教研究,四川南充,637000;3. 川北医学院 附属医院乳腺外科,四川南充,637000 |
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| 摘 要： | 目的：通过检测 Annexin A1在甲状腺乳头状癌中的表达,探讨其与甲状腺乳头状癌的关系与意义。方法取69例甲状腺乳头状癌患者癌组织及癌旁正常组织切片,使用二步法免疫组织化学染色观察 Annexin A1在甲状腺乳头状癌和癌旁正常组织中的表达情况。结果Annexin A1在癌组织中高表达。癌组织表达61例(88.41%),癌旁正常组织表达6例(8.69%),差异有统计学意义(P <0.05)；在淋巴结转移和肿瘤直径大于或等于1 cm 的患者中,Annexin A1表达高于肿瘤小于1 cm 的患者,差异有统计学意义(P <0.05)。结论甲状腺乳头状癌组织中 Annexin A1的高表达,提示其可能为甲状腺乳头状癌潜在的生物学标记物。
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| 关 键 词： | 甲状腺乳头状肿瘤 Annexin A1 免疫组织化学 |
Expression and clinical significance of annexin A1 in different stages of papillary thyriod carcinoma patients |
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| Abstract: | Objective To explore the correlations between Annexin A1 protein expression and clinicopathological character-istics in carcinoma of papillary thyroid.Methods The different expressions of annexin A1 in papillary thyroid tissue and para-cari-noma tissue were investigated by immunohistochemistry.Results Among 69 samples tissues of papillary thyriod carcinoma,the positive rate of annexin A1 was higher than that of 69 para-carcinoma tissues(88.41%vs .8.69%),there was a significant difference (P <0.05).Furthermore,the expression of annexin A1 was correlation with the lymph node metastasis and tumor size,which was higher in ≥1 cm diameter of tumor(P <0.05).Conclusion High AnnexinA1 positive expression in papillary thyroid cancer tissues is associated with tumor malignant progression,which might be a valuable predictor and potential target for the diagnosis and treat-ment of papillary thyroid carcinoma. |
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| Keywords: | carcinoma of papilly thyroid neoplasms annexin A1 immunohistochemistry |
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