| Peptide-drug conjugates(PDCs): a novel trend of research and development on targeted therapy,hype or hope? |
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| 作者姓名： | Chen Fu Lifeng Yu Yuxi Miao Xinli Liu Zhaojin Yu Minjie Wei |
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| 作者单位： | 1. Department of Pharmacology, School of Pharmacy, China Medical University;2. Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation, China Medical University;4. Department of Digestive Oncology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital&Institute |
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| 摘 要： | Peptide-drug conjugates(PDCs) are the next generation of targeted therapeutics drug after antibody-drug conjugates(ADCs), with the core benefits of enhanced cellular permeability and improved drug selectivity. Two drugs are now approved for market by US Food and Drug Administration(FDA), and in the last two years, the pharmaceutical companies have been developing PDCs as targeted therapeutic candidates for cancer, coronavirus disease 2019(COVID-19), metabolic diseases, and so on.The therapeutic ...
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| 收稿时间： | 2022-05-09 |
| 本文献已被 ScienceDirect 等数据库收录！ |
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