保妇康栓联合干扰素栓对宫颈HPV感染患者HPV DNA负荷量、炎性因子及免疫功能的影响

目的分析保妇康栓联合干扰素栓对宫颈人乳头瘤病毒(HPV)感染患者HPV脱氧核糖核酸(HPV DNA)负荷量、炎性因子及免疫功能的影响。方法从2017年2月-2019年1月佛山市三水区人民医院收治的宫颈HPV感染患者中选取80例进行研究,以随机数字表法分为观察组和对照组,每组40例。对照组接受干扰素治疗,观察组在对照组基础上加用保妇康栓治疗,比较2组治疗效果及治疗前后HPV DNA负荷量、炎性因子及免疫功能指标。结果观察组治疗总有效率为95. 00%,高于对照组的80. 00%(P <0. 05);2组治疗前HPV DNA负荷量无明显差异(P>0. 05),观察组治疗后HPV DNA负荷量低于对照组(P <0. 05);2组治疗前高敏C-反应蛋白(hs-CRP)、降钙素原(PCT)、白介素-6(IL-6)水平无明显差异(P>0. 05),观察组治疗后炎性因子水平低于对照组(P <0. 05);2组治疗前CD3^+、CD4^+、CD8^+数值无明显差异(P> 0. 05),观察组治疗后上述免疫功能指标与对照组比较差异有统计学意义(P <0. 05)。结论保妇康栓联合干扰素栓可有效降低宫颈HPV感染患者HPV DNA负荷量,控制炎性因子水平,调节机体免疫功能,效果确切。

Effect of Baofukang suppository combined with interferon suppository on HPV DNA load,inflammatory factors and immune function in patients with cervical HPV infection

Objective To investigate the effect of Baofukang suppository combined with interferon suppository on HPV deoxyribonucleic acid(DNA) load,inflammatory factor and immune function in patients with cervical human papillomavirus(HPV) infection. Methods A total of 80 patients with cervical HPV infection treated in People’s Hospital of Sanshui District from February 2017 to January 2019 were selected for research. They were divided into observation group and control group by random number table method,with 40 cases in each group. The control group received interferon treatment,and the observation group added Baofukang suppository on the basis of the control group,observed the therapeutic effects and HPV DNA load,the inflammatory factors and immune function before and after treatment of two groups. Results The total effective rate of the observation group was 95. 00%,compared with the control group(80. 00%),significantly higher(P < 0. 05).There was no significant difference in HPV DNA load between the two groups before treatment(P > 0. 05),after treatment,the HPV DNA load in the observation group was compared with the control group,significantly lower,the difference was statistically significant(P < 0. 05). There were no significant differences in high-sensitivity C-reactive protein(hs-CRP),procalcitonin(PCT),and interleukin-6(IL-6) between the two groups before treatment(P > 0. 05). After treatment,the level of inflammatory factors in the observation group were compared with the control group,significantly lower(P < 0. 05). There were no significant difference in CD3+,CD4+ and CD8+ between the two groups before treatment(P > 0. 05). The above immune function indexes in the observation group were compared with the control group,significantly different(P < 0. 05).Conclusion Baofukang suppository combined with interferon suppository can effectively reduce HPV DNA load in patients with cervical HPV infection,control the level of inflammatory factors,and regulate the immune function of the body,the effect is exact and worth promoting.