Tango7 directs cellular remodeling by the Drosophila apoptosome |
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Authors: | Alejandro D'Brot Po Chen Mahesh Vaishnav Shujun Yuan Christopher W. Akey John M. Abrams |
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Affiliation: | 1.Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA;;2.Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94158, USA;;3.Department of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts 02118, USA |
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Abstract: | It is now well appreciated that the apoptosome, which governs caspase-dependent cell death, also drives nonapoptotic caspase activation to remodel cells. However, the determinants that specify whether the apoptosome acts to kill or remodel have yet to be identified. Here we report that Tango7 collaborates with the Drosophila apoptosome to drive a caspase-dependent remodeling process needed to resolve individual sperm from a syncytium. In these cells, Tango7 is required for caspase activity and localizes to the active apoptosome compartment via its C terminus. Furthermore, Tango7 directly stimulates the activity of this complex in vitro. We propose that Tango7 specifies the Drosophila apoptosome as an effector of cellular remodeling. |
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Keywords: | apoptosome cellular remodeling caspase activity apoptosis cell death |
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