| CAR-T细胞治疗突破实体肿瘤微环境新策略的研究进展 |
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| 引用本文： | 关丽萍,蒋敬庭,吴昌平.CAR-T细胞治疗突破实体肿瘤微环境新策略的研究进展[J].临床肿瘤学杂志,2020,25(3):264-267. |
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| 作者姓名： | 关丽萍 蒋敬庭 吴昌平 |
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| 作者单位： | 213003,江苏常州 苏州大学附属第三医院肿瘤生物诊疗中心 苏州大学细胞治疗研究院 |
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| 基金项目： | 国家重点研发资助项目(2018YFC1313400);国家科技支撑计划资助项目(2015BAI12B12);国家自然科学基金海外及港澳学者合作研究资助项目(31729001);国家自然科学基金资助项目(31570877,31570908);江苏省重点研发计划专项资助项目(BE2018645)。 |
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| 摘 要： | 免疫治疗可通过提高患者自身免疫力以达到抗肿瘤目的,其中嵌合型抗原受体修饰T细胞(chimeric antigen receptor modified T cells,CAR-T)在血液系统肿瘤中已显现出良好疗效。实体肿瘤微环境(tumor microenvironment,TME)中免疫抑制细胞及分子等可限制CAR-T细胞在肿瘤部位浸润及其在浸润部位产生细胞毒作用。因此CAR-T细胞治疗在血液系统肿瘤中的显著疗效未在实体肿瘤中呈现。本文就如何突破TME限制,提高CAR-T细胞归巢能力及细胞毒作用,从而提高其在实体瘤中的疗效做一综述。
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| 关 键 词： | 实体肿瘤 嵌合型抗原受体 肿瘤微环境 |
Progression of new strategy of CAR-T cell therapy to break through solid tumor microenvironment |
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| GUAN Liping,JIANG Jingting,WU Changping.Progression of new strategy of CAR-T cell therapy to break through solid tumor microenvironment[J].Chinese Clinical Oncology,2020,25(3):264-267. |
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| Authors: | GUAN Liping JIANG Jingting WU Changping |
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| Institution: | (Department of Tumor Biological Treatment,the Third People s Hospital Affiliated to Soochow University,Institute of Cell Therapy,Soochow University,Changzhou 213003,China) |
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| Abstract: | Immunotherapy can improve the patient's own immunity to achieve the purposes of anti-tumor,wherein chimeric antigen receptor modified T cells(CAR-T)have shown unparalleled durable responses in hematological tumors.Immunosuppressive cells and molecules in the tumor microenvironment(TME)limit the infiltration and cytotoxicity of CAR-T cells at the tumor site.Therefore,the significant efficacy of CAR-T cell therapy in hematological tumors is not present in solid tumors.Here we take an overview of how to break through the TME restriction,improve the homing ability and cytotoxicity of CAR-T cells,and thus improve its efficacy in solid tumors. |
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| Keywords: | Solid tumors Chimeric antigen receptor(CAR) Tumor microenvironment(TME) |
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