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microRNA-214在胃癌组织中的表达情况及临床意义
引用本文:谢良宝,高凌,冯亚光,张玉文.microRNA-214在胃癌组织中的表达情况及临床意义[J].癌症进展,2020(4):402-405.
作者姓名:谢良宝  高凌  冯亚光  张玉文
作者单位:商丘市第一人民医院胃肠肝胆外科;商丘市第一人民医院病理科
摘    要:目的探讨微小RNA(miRNA)-214在胃癌组织中的表达情况及临床意义。方法选取47例胃癌患者的胃癌组织标本及对应的癌旁组织标本,采用实时荧光定量聚合酶链反应(qRT-PCR)检测胃癌组织(n=47)和癌旁组织(n=47)中miRNA-214的表达情况,分析miRNA-214表达与胃癌患者临床特征的关系。结果胃癌患者胃癌组织中miRNA-214的相对表达量明显高于癌旁组织(P<0.01)。不同TNM分期、分化程度、淋巴结转移情况的胃癌患者胃癌组织中miRNA-214的相对表达量比较,差异均有统计学意义(P<0.05);不同性别、年龄、肿瘤直径的胃癌患者胃癌组织中miRN A-214的相对表达量比较,差异均无统计学意义(P>0.05)。3年无瘤生存的23例胃癌患者胃癌组织中miRNA-214的相对表达量与3年复发或转移的24例胃癌患者胃癌组织中miRNA-214相对表达量比较,差异有统计学意义(P<0.05)。miRNA-214高表达、TNM分期为Ⅲ~Ⅳ期、有淋巴结转移和低分化均是胃癌患者3年无瘤生存的独立危险因素(P<0.05)。结论miRNA-214在胃癌组织中呈相对高表达,miRNA-214高表达、TNM分期为Ⅲ~Ⅳ期、有淋巴结转移和低分化均是胃癌患者预后的独立危险因素。

关 键 词:miRNA-214  胃癌组织  癌旁组织  淋巴结转移  临床特征

Expression of miRNA-214 in gastric cancer and its clinical significance
XIE Liangbao,GAO Ling,FENG Yaguang,ZHANG Yuwen.Expression of miRNA-214 in gastric cancer and its clinical significance[J].Oncology Progress,2020(4):402-405.
Authors:XIE Liangbao  GAO Ling  FENG Yaguang  ZHANG Yuwen
Institution:(Department of Gastrointestinal Hepatobiliary Surgery the First People’s Hospital of Shangqiu,Shangqiu 476100,He’nan,China;Department of Pathology,the First People’s Hospital of Shangqiu,Shangqiu 476100,He’nan,China)
Abstract:Objective To investigate the expression and clinical significance of microRNA-214(miRNA-214)in gastric cancer.Method The specimens of gastric cancer tissues and adjacent tissues of 47 patients with gastric cancer were selected.The quantitative real-time polymerase chain reaction(qRT-PCR)was utilized in detecting the expression of miRNA-214 in gastric cancer tissues(n=47)and adjacent tissues(n=47),besides,the relationship between the expression of miRNA-214 and the clinical characteristics of gastric cancer patients was determined.Result The relative expression of miRNA-214 in gastric cancer tissues was significantly higher than that in normal tissues(P<0.01).The expression of miRNA-214 varied among patients with different TNM stage,degree of differentiation and lymph node metastasis(P<0.05);while it was independent of sex,age and tumor diameter in patients with gastric cancer(P>0.05).The relative expression level of miRNA-214 in gastric cancer tissues of 23 patients with 3-year tumor-free survival was statistically significant compared with that of 24 patients with 3-year recurrence or metastasis(P<0.05).High expression of miRNA-214,TNM stage ofⅢ-Ⅳ,and positive lymph node metastasis as well as lower degree of differentiation are the independent risk factors for the 3-year tumor-free survival of the patients with gastric cancer(P<0.05).Conclusion The relative high expression of miRNA-214 is present in the gastric cancer tissues,besides,high expression of miRNA-214,TNM stage ofⅢ-Ⅳ,and positive lymph node metastasis as well as lower degree of differentiation are the independent risk factors for the prognosis of the patients with gastric cancer.
Keywords:miRNA-214  gastric cancer tissue  adjacent tissue  lymph node metastasis  clinical characteristic
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