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Cryptococcal meningitis in a patient treated with infliximab
Authors:Muñoz Patricia  Giannella Maddalena  Valerio Maricela  Soria Teresa  Díaz Fernando  Longo Javier Lopez  Bouza Emilio
Institution:1. Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario “Gregorio Marañón”, University of Madrid, 28007 Madrid, Spain;2. Department of Clinical Medicine, Policlinico Umberto I, University “La Sapienza,” Rome, Italy;3. Department of Neurology, Hospital General Universitario “Gregorio Marañón”, University of Madrid, 28007 Madrid, Spain;4. Department of Rheumatology, Hospital General Universitario “Gregorio Marañón”, University of Madrid, 28007 Madrid, Spain
Abstract:Infliximab, a tumor necrosis factor-alpha inhibitor, is increasingly used for the therapy of different inflammatory conditions. We report the first case of cryptococcal meningitis in a patient treated with infliximab and other immunosuppressive agents, and review a further 5 reported cryptococcal infections. All of them involved fungal pneumonia. Outcome was favorable in all cases.
Keywords:Infliximab  Cryptococcus neoformans  Rheumatoid arthritis  Immunosuppressed host  Meningitis  Pneumonia
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