| 一氧化氮与帕金森病大鼠模型神经损伤的研究 |
| |
| 引用本文： | 周国庆,周孝达,金泳清,陈光辉,王桂松.一氧化氮与帕金森病大鼠模型神经损伤的研究[J].中风与神经疾病杂志,2000,17(5):288-289. |
| |
| 作者姓名： | 周国庆 周孝达 金泳清 陈光辉 王桂松 |
| |
| 作者单位： | 1. 南京军区南京总院神经内科,江苏,南京,210002
2. 上海第二医科大学仁济医院神经内科,上海,200023 |
| |
| 摘 要： | 目的 研究一氧化氮（ＮＯ）在帕金森病（ＰＤ）大鼠模型神经损伤中的作用。方法 用高效液相色谱电化学法（ＨＰＬＣ－ＥＴ）及还原型辅酶Ⅱ（ＮＡＤＰＨ）黄递酶组化法观察ＮＯ在ＰＤ大鼠模型神经损伤中的作用。结果 神经型一氧化氮合成酶（ｎＮＯＳ）抑制剂７－硝基吲唑（７－ＮＩ）明显减少６－羟基多巴胺（６－ＯＨＤＡ）引起的纹状体多巴胺及其代谢产物的降低（Ｐ〈０．０１）；纹状体ＮＡＤＰＨ黄递酶阳性神经元可抵抗６－Ｏ
|
| 关 键 词： | 一氧化氮 帕金森病 6－羟基多巴胺 动物模型 |
| 修稿时间： | 1999-03-16 |
Studies on nitric oxide and neuronal damage in rat model of Parkinson's disease |
| |
| ZHOU Guo qing,ZHOU Xiao da,JIN Yong qing,et al..Studies on nitric oxide and neuronal damage in rat model of Parkinson''''s disease[J].Journal of Apoplexy and Nervous Diseases,2000,17(5):288-289. |
| |
| Authors: | ZHOU Guo qing ZHOU Xiao da JIN Yong qing |
| |
| Abstract: | Objective To investigate the role of nitric oxide (NO) in neuronal damage in the rat model of Parkinson ,s disease (PD). Methods The role of nitric oxide (NO) in 6 hydroxydopamine(6 OHDA) treated rat model of PD was investigated by using HPLC ET and NADPH diaphorase histochemistry. Results 7 nitroindazole (7 NI),a selective inhibitor of neuronal nitric oxide synthase (nNOS) may significantly decrease 6 OHDA induced deplection of striatal dopamine and its metabolite,and the NADPH diaphorase containing neuron in striatum could resist the 6 OHDA neurotoxicity. Conclusions Neuronally derived NO participate in the neurotoxic mechanism of the rat model of PD |
| |
| Keywords: | NO Parkinson s disease 6 OHDA |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
