红景天对含表柔比星方案化疗患者的血清肌钙蛋白Ⅰ、心肌背向散射积分及左室射血分数的影响 |
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引用本文: | 沈伟生,高春恒,张华,邓立春,袁明,张瑶,奚蕾.红景天对含表柔比星方案化疗患者的血清肌钙蛋白Ⅰ、心肌背向散射积分及左室射血分数的影响[J].中国中西医结合杂志,2010,30(12):1250-1252. |
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作者姓名: | 沈伟生 高春恒 张华 邓立春 袁明 张瑶 奚蕾 |
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作者单位: | 1 . 东南大学医学院附属江阴医院肿瘤科(江苏214400);2. 东南大学医学院附属江阴医院超声科;3. 东南大学医学院附属江阴医院心内科 |
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基金项目: | 江苏省无锡市卫生系统07-08年度中医药科研资助项目(No.ZXM0806) |
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摘 要: | 目的探讨红景天对应用表柔比星(EPI)后患者的心肌保护作用。方法应用EPI3个化疗周期后出现心肌受损的患者42例,随机分为中药红景天组(治疗组)和对照组,比较1个月后血清肌钙蛋白Ⅰ(cTnⅠ)、心肌背向散射积分(IBS)及左室射血分数(LVEF)的变化及症状改善情况。结果两组患者治疗后cTnⅠ分别为(0.54±0.05)mg/L、(0.98±0.03)mg/L,IBS分别为(55.23±5.72)%、(61.23±5.96)%;LVEF分别为(68±3)%、(57±2)%,两组比较,差异有统计学意义(P〈0.05)。结论红景天可明显改善应用EPI后患者的心功能,抑制cTnI和IBS的升高。
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关 键 词: | 红景天 表柔比星 肌钙蛋白Ⅰ 心肌背向散射积分 左室射血分数 |
Effect of Rhodiola on Serum Troponin 1,Cardiac Integral Backscatter and Left Ventricle Ejective Fraction of Patients Who Received Epirubicin-contained Chemotherapy |
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Authors: | SHEN Wei-sheng GAO Chunheng ZHANG Hua |
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Institution: | SHEN Wei-sheng,GAO Chunheng,ZHANG Hua,et al Affiliated Jiangyin Hospital,Medical College of Southeast University,Jiangsu (214400) |
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Abstract: | Objective To investigate the myocardial protective effect of Rhodiola on patients who received epidoxorubicin (EPI) treatment.Methods Forty-two patients with myocardial damage who received 3 courses of EPI contained chemotherapy were randomly and equally assigned to two groups,the Rhodiola treated group and the control group.After 1-month treatment,the changes in serum troponin Ⅰ (cTnⅠ) level,cardiac integral backscatter (IBS),and left ventricle ejective fraction (LVEF) in patients were observed and compared between groups.Results Levels of cTnI in the treated group and control group were (0.54±0.05)mg/L and (0.98±0.03)mg/L respectively,IBS were 55.23±5.72 scores and 61.23±5.96 scores,and LVEF (%) were 68±3 and 57±2 respectively,all showed significant differences between groups (P0.05).Conclusion Rhodiola can improve cardiac function,and suppress the increase of serum cTnⅠ level and IBS in patients who received EPI treatment. |
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Keywords: | rhodiola epirubicin troponin Ⅰ cardiac integral backscatter left ventricle ejective fraction |
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