HLA antibodies in pediatric heart transplantation |
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Authors: | Ho Eric K Vasilescu Elena R Vlad George Marboe Charles C Addonizio Linda J Suciu-Foca Nicole |
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Affiliation: | Departments of Pathology & Cell Biology Pediatrics, Columbia University, New York, NY 10032, USA. |
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Abstract: | We have analyzed the impact of anti-HLA antibodies present in the patients' circulation prior and/or following heart transplantation in a population of 108 pediatric recipients. Anti-HLA class I and class II antibodies were monitored by traditional CDC using donor and panel T and B lymphocytes and by SPA for detection of DSA. There was a highly significant correlation between the development of AMR and presence of CDC- or SPA-detected DSA. However, the fraction of the transplant population which remained AMR-free was much higher among patients with SPA-detected compared to CDC-detected DSA. Furthermore, long-term graft survival was negatively affected only by cytotoxic, complement-fixing anti-HLA class I antibodies developing following transplantation. Anti-HLA class I or class II antibodies detected by SPA had no effect on long-term survival rates. |
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Keywords: | pediatric heart transplant anti‐HLA antibodies solid‐phase assays complement‐mediated cytotoxicity antibody‐mediated rejection post‐transplant monitoring of antibodies |
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