Pre-S_2抗原在乙肝疫苗中的免疫作用的探讨 |
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引用本文: | 欧阳佩英,陆培华.Pre-S_2抗原在乙肝疫苗中的免疫作用的探讨[J].现代免疫学,1992,12(3):155-158. |
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作者姓名: | 欧阳佩英 陆培华 |
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作者单位: | 上海医科大学,上海医科大学,上海医科大学,上海医科大学,上海医科大学,上海医科大学,上海第一妇婴保健院,上海第一妇婴保健院,上海第一妇婴保健院,上海第一妇婴保健院,上海生物制品研究所 上海 200032,上海 200032,上海 200032,上海 200032,上海 200032,上海 200032 |
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摘 要: | 比较三种乙型肝炎血源疫苗和一种重组DNA(r-DNA)疫苗诱导Pre-S_2抗体阳性率与阻断乙型肝炎病毒母婴传播的有效率,其中rDNA疫苗不含有Pre-S_2蛋白,免疫后不产生Pre-S_2抗体,加热灭活疫苗按3μg与6μg两种剂量免疫后,半数以上对象均可产生Pre-S_2抗体,甲醛一步法灭活疫苗免疫后有30%婴儿产生Pre-S_2抗体。阻断母婴传播的有效率分别为:rDNA疫苗72.2%,甲醛一步法灭活疫苗70.1%,加热灭活疫苗3μg组35.6%,6μg组71.9%。疫苗免疫效果同HBsAg含量有关,似同Pre-S_2蛋白关系不明显。免疫后抗HBs阳性率与反映抗HBs含量的S/N值均同Pre-S_2抗体阳性率没有明显联系。Pre-S_2蛋白似非决定乙肝疫苗有效率的主要成分,而疫苗中的S蛋白含量对疫苗的免疫效果起十分重要作用。
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关 键 词: | 乙型肝炎 疫苗 Pre-S2抗原 免疫 |
STUDY ON THE EFFECT OF PRE-S2 IN HBV VACCINE FOR ITS US EFULNESS |
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Abstract: | Four groups of infants from HBV carrier mothers were vaccinated with different HBV vaccines (1.3μg doses, flash-heating inactivated. 2. 6μg doses. 3. 20μg doses, formalin inactivated. 4.8μg doses of recombinant hepatitis B vaccine.)at birth,one and six months. Only the last vaccine did not contain the protein Prc-S2. The protective effecacy in infants at 12 months of age was 35.6% in the 3μg group, 71.3% in the 6μg group, 70.1% in the 20μg of formalin inactivated group and 72.2% for recombinant HBV vaccine.These results indicated that HBV vaccines could offer high post exposure protection when used in high doses.But the protein pre-S2 did not play an important role in this study .The mechanism of the protection offered by HBV vaccine needs further investigation. |
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