|
|||||
|
|
Somatosensory System Deficits in Schizophrenia Revealed by MEG during a Median-Nerve Oddball Task |
|
| Authors: | Ming-Xiong Huang Roland R Lee Kathleen M Gaa Tao Song Deborah L Harrington Cathy Loh Rebecca J Theilmann J Christopher Edgar Gregory A Miller Jose M Canive Eric Granholm |
| Institution: | 1. Research, Radiology, and Psychiatry Services, VA San Diego Healthcare System, San Diego, CA, USA 2. Radiology Imaging Laboratory, Department of Radiology, University of California, San Diego, 3510 Dunhill Street, San Diego, CA, 92121, USA 3. Department of Psychiatry, University of California, San Diego, San Diego, CA, USA 4. Department of Radiology, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA 5. Departments of Psychology and Psychiatry and Beckman Institute Biomedical Imaging Center, University of Illinois at Urbana–Champaign, Urbana, IL, USA 6. Department of Psychiatry, University of New Mexico, Albuquerque, NM, USA 7. Psychiatry Research Program, New Mexico VA Health Care System, Albuquerque, NM, USA 8. Departments of Psychiatry and Neurosciences, University of New Mexico, Albuquerque, NM, USA |
| Abstract: | Although impairments related to somatosensory perception are common in schizophrenia, they have rarely been examined in functional imaging studies. In the present study, magnetoencephalography (MEG) was used to identify neural networks that support attention to somatosensory stimuli in healthy adults and abnormalities in these networks in patient with schizophrenia. A median-nerve oddball task was used to probe attention to somatosensory stimuli, and an advanced, high-resolution MEG source-imaging method was applied to assess activity throughout the brain. In nineteen healthy subjects, attention-related activation was seen in a sensorimotor network involving primary somatosensory (S1), secondary somatosensory (S2), primary motor (M1), pre-motor (PMA), and paracentral lobule (PCL) areas. A frontal–parietal–temporal “attention network”, containing dorsal- and ventral–lateral prefrontal cortex (DLPFC and VLPFC), orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), superior parietal lobule (SPL), inferior parietal lobule (IPL)/supramarginal gyrus (SMG), and temporal lobe areas, was also activated. Seventeen individuals with schizophrenia showed early attention-related hyperactivations in S1 and M1 but hypo-activation in S1, S2, M1, and PMA at later latency in the sensorimotor network. Within this attention network, hypoactivation was found in SPL, DLPFC, orbitofrontal cortex, and the dorsal aspect of ACC. Hyperactivation was seen in SMG/IPL, frontal pole, and the ventral aspect of ACC in patients. These findings link attention-related somatosensory deficits to dysfunction in both sensorimotor and frontal–parietal–temporal networks in schizophrenia. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |