Analysis of T-cell receptor expressing lymphocytes infiltrating squamous cell carcinomas of the upper aerodigestive tract |
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Authors: | P. G. Liavaag A. C. Johannessen R. Nilsen R. Jonsson |
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Affiliation: | (1) Department of Otolaryngology/Head & Neck Surgery, Haukeland University Hospital, N-5021 Bergen, Norway;(2) University of Bergen, Department of Oral Pathology and Forensic Odontology, Bergen, Norway;(3) Laboratory for Oral Microbiology, University of Bergen, Bergen, Norway;(4) Broegelmann Research Laboratory for Microbiology, Department of Microbiology and Immunology, The Gade Institute, University of Bergen, Bergen, Norway |
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Abstract: | T-lymphocytes expressing T -cell receptors (TCRs) of the / type have been suggested to play an important role in mucosal defense against infection and neoplastic transformation. In this study, an immunohistochemical investigation was performed on the distribution of / and / TCRs among tumor-infiltrating lymphocytes. Thirteen patients with squamous cell carcinomas of the upper aerodigestive tract were studied, using monoclonal antibodies and an avidin-biotin-peroxidase technique. Most of the T-cells had an / TCR. Only 1.6% of the T-cells within the cancer tissue and 1.2% of the T-cells in the parenchyma adjacent to the cancer tissue expressed /gd TCRs. These results are consistent with the results of similar studies in bronchial and breast carcinomas. Biopsies from normal oral mucosa in nine healthy individuals showed that 1.3% of the T -cells within the epithelium and 1.0% of those in the lamina propria adjacent to the epithelium expressed / TCRs. Quantitatively the results do not support the theory that / T-cells play an important role in the immunological response against cancer tissue in the mucosa of the upper aerodigestive tract. The functional role of these cells in the mucosa and in response to carcinomas is, however, still uncertain. |
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Keywords: | T-cell receptors /content/ll11588602576wtk/xxlarge947.gif" alt=" gamma" align=" MIDDLE" BORDER=" 0" >/ /content/ll11588602576wtk/xxlarge948.gif" alt=" delta" align=" BASELINE" BORDER=" 0" > T-cells Squamous cell carcinomas Aerodigestive tract |
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