Intracolonic fat inhibits gastric acid secretion independent of gastrin release in the dog |
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Authors: | Dr Tsukuru Hashimoto MD Dr Felix Lluis MD Guillermo Gomez MD Freddie L C Hill BS Dr George H Greeley Jr PhD James C Thompson MD |
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Institution: | (1) Department of Surgery, The University of Texas Medical Branch, 77550 Galyeston, Texas;(2) Present address: First Department of Surgery, Osaka University Medical School, Osaka, Japan;(3) Present address: Department of Surgery, Hospital Sta. Creu i Sant Pau, Universidad Autonoma de Barcelona, Spain |
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Abstract: | The purpose of this study was to examine the effect of perfusion of the colon with a fatty acid (oleic acid) on peptone-stimulated gastric acid secretion and release of gastrin in conscious dogs. Gastric acid secretion was monitored by continuous intragastric titration. Perfusion of the colon with sodium oleate (24 mmol/hr) inhibited gastric acid secretion (14.2±2.6 meq/hr) stimulated by a peptone meal (1%) significantly (P<0.05) when compared to perfusion of the colon with saline alone (20.1±1.6 meq/hr). The serum elevation, in gastrin in response to intragastric instillation of the peptone meal was not affected by the colonic perfusion of oleic acid. Plasma concentrations of peptide YY (PYY) increased significantly in response to perfusion of the colon with saline or sodium oleate, and the integrated release of PYY in response to sodium oleate 16.9±2.8 ng (60–120) min/ml] was significantly greater than the response to saline 3.1±0.7 ng (60–120) min/ml]. The results of this study indicate that inhibition of gastric acid secretion by perfusion of the colon with fat is not due to an inhibition of gastrin release. In addition, because PYY is an inhibitor of gastric acid secretion, it is possible that PYY participates as an inhibitor of gastric acid secretion by the colon.Supported by grants from the National Institutes of Health (5R37 DK 15241, P01 DK 35608) and a NATO collaborative research grant (0014/89). |
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Keywords: | enterogastrone peptone colon intragastric titration |
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