股骨头坏死愈胶囊对家兔早期ANFH后股骨头生物力学影响的实验研究

目的研究股骨头坏死愈胶囊对家兔早期ANFH后股骨头生物力学的影响,探讨其对激素性股骨头缺血坏死的防治效果及作用机制。方法采用28只新西兰大白兔为研究对象,随机取10只为正常组,其余均进行造模,造模4w后,随机取正常组、造模组各2只兔做组织病理学观察,证实造模成功。将造模组随机分为治疗组和模型组,治疗组灌服股骨头坏死愈胶囊药液,正常组及模型组灌服生理盐水。用药3个月后,处死全部动物,对股骨头行生物力学性能检测,统计分析各组数据。结果模型组的各项力学指标（除最大位移、最大应变）均明显低于正常组（P〈0.01）,治疗组的弹性模量、最大载荷、最大应力、刚度等力学指标与正常组相比无显著性差异（P〉0.05）。结论股骨头坏死愈胶囊能明显提高家兔早期ANFH后股骨头的力学强度,治疗ANFH不但应改善血运,同时还对有病变的股骨头提供足够的力学支撑。

Experimental Study of Biomechanical Effects of Gugutou Huaisi Yu Jiaonang on Avascular Necrosis of Femoral Head at Early Phase in Rabbits

Objective To study the biomechanical effects of Gugutou Huaisi Yu Jiaonang（capsule for promoting the healing of necrosis of femoral head）on avascular necrosis of femoral head（ANFH）at early phase in rabbits and discuss its prevention and mechanism on steroid-induced ANFH.Methods 28 New Zealand big rabbits were selected as the study objects.10 rabbits of them were randomized to be in normal group and the rest were modeled.4 weeks after modeling,2 rabbits were randomized from normal group and omechanical strength of femoral head after ANFH at early phase in rabbits. It not only improves blood circulation in ANFH treatment, but also provides adequate mechanical support for necrotic femoral head.