吗啡对大鼠肾功能部分血浆生化指标影响的评估

目的：研究吗啡依赖大鼠血浆肾功能的变化。方法：建立吗啡依赖及戒断大鼠模型，50只Wistar大鼠随机分成对照组、3d给药组、7d给药组、3d戒断组及7d戒断组，检测血液生化指标尿素氮（BUN）、肌酐（CREA）和尿酸。结果：与对照组相比，7d给药组、3d戒断组和7d戒断组血浆BUN的含量明显升高, 其中7d戒断组血浆BUN的含量升高最为显著（P＜0.01）；CREA含量在给药3d时开始升高，给药7d后稍有下降，停药后又升高，但各组含量与对照组相比，均无统计学意义；吗啡给药组血浆尿酸水平明显高于对照组（P＜0.05）。结论：吗啡给药对肾功能有一定程度的损害，并可能存在持续性，不能在停药后立即消除。

Morphine affects the renal function in rats

Objective: To investigate the effect of morphine on renal function.Methods: Fifty Wistar rats were randomly divided into five groups: the control group,the 3 d administration group,the 7 d administration group,the 3 d withdrawal group and the 7 d withdrawal group.The concentration of urea nitrogen(BUN), creatinine(CREA) and uric acid in the plasma were determined.Results: Compared with the control group,the plasma BUN concentration was increased in the 7 d administration group and the two withdrawal groups,and it was the highest in the the 7 d withdrawal group.However,there was no significant difference of the plasma CREA between the two administration groups and the control group.Compared with the control group,the concentration of the plasma uric acid was increased in the two morphine administration groups.Conclusion: Morphine exposure can affect the renal function to some degree,which does not immediately vanish after morphine administration.