| 星形胶质细胞升高基因-1与肿瘤血管生成的关系 |
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| 引用本文： | 柯尊富,李淑华,韩安家,王芬,王冉,连家燕,王连唐. 星形胶质细胞升高基因-1与肿瘤血管生成的关系[J]. 现代医学仪器与应用, 2011, 0(6) |
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| 作者姓名： | 柯尊富 李淑华 韩安家 王芬 王冉 连家燕 王连唐 |
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| 作者单位： | 中山大学附属第一医院病理科; |
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| 基金项目： | 国家自然科学基金(30900650H1615); 广东省自然科学基金(9451008901002146) |
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| 摘 要： | AEG-1对肿瘤多种生物学特性均有促进作用,并与肿瘤血管生成密切相关。实验证实AEG-1过度表达的肿瘤部分新生血管较多,AEG-1也可以提高VEGF启动子的活性以及相关分子的表达水平。与AEG-1介导血管生成有关的分子包括PI3k/Akt、Tie2、Ang1、H-ras和HIF-1α等。在信号转导途径中最为重要的是PI3k/Akt信号通路,PI3k/Akt起到联系H-ras和AEG-1的作用,并介导由AEG-1引起的Ang1/Tie2下游靶位点的激活。NF-κB,H-ras/MEK在AEG-1介导的血管生成中也起到重要作用。
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| 关 键 词： | 星形胶质细胞升高基因1 血管生成 分子机制 |
The relationship of AEG-1 with tumor angiogenesis |
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| KE Zunfu,LI Shuhua,HAN Anjia,WANG Fen,WANG Ran,LIAN Jiayan,WANG Liantang. The relationship of AEG-1 with tumor angiogenesis[J]. , 2011, 0(6) |
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| Authors: | KE Zunfu LI Shuhua HAN Anjia WANG Fen WANG Ran LIAN Jiayan WANG Liantang |
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| Affiliation: | KE Zunfu,LI Shuhua,HAN Anjia,WANG Fen,WANG Ran,LIAN Jiayan,WANG Liantang (Department of Pathology,the First Affiliated Hospital of Sun Yat-sen University,Guangdong,Guangzhou 510080,China) |
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| Abstract: | AEG-1 plays an important role in many biological characteristics of tumor and is closely correlated with tumor angiogenesis.Many experiments established that AEG-1 overexpression in tumor is positively correlated with angiogenesis.Simultaneously,it can also activate the promotor of VEGF and has an effect on the expression level of VEGF-related molecules,including PI3k/Akt,Tie2,Ang1,H-ras and HIF-1a.PI3k/Akt signal pathway is one of important pathways that contacts H-ras and AEG-1,and mediates the activation... |
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| Keywords: | Astrocyte elevated gene-1 Angiogenesis Molecular mechanism |
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