Circulating serum interferon andits effect on the activity of human natural killer cells |
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Authors: | S B Cheknev Ya G Ashmanova A D Pritsker O L Latysheva |
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Institution: | (1) Laboratory of Immunochemistry, Department of Interferons, N. F. Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow;(2) Department of Neurology, N. I. Pirogov Municipal Hospital No. 1, Moscow |
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Abstract: | The interferon content in the plasma of 6 healthy donors and 10 patients with multiple sclerosis and the effect of an 1-h
treatment of mononuclear cells with autologous plasma on their natural killer activity are studiedin vitro using3H-uridine-labeled (3 μCi/ml) human erythromyeloleukosis cells K-562. The serum interferon content in healthy donors is 2.3±0.82
IU/ml, whereas that in patients is higher: 5.2±0.8 IU/ml. Autologous plasma does not affect the activity of natural killer
cellsin vitro, whereas it increases the cytotoxicity of mononuclear cells obtained from patients with multiple sclerosis by 35–64%.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
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12, pp. 619–622, December, 1994
Presented by S. V. Prozorovskii, Member of the Russian Academy of Medical Sciences |
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Keywords: | circulating interferon natural killer activity |
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