早产儿脑室周围白质软化研究现状

脑室周围白质软化(PVL)是早产儿脑损伤主要神经病理学形式,与长期神经行为缺陷密切相关。PVL病因复杂,涉及到解剖学、生理学、细胞学及生物学等方面。其发病机制不甚清楚,自由基作用、兴奋毒性作用及感染、细胞因子等参与PVL形成。PVL无特异性症状,诊断依赖于影像学检查。PVL目前尚无特效疗法,一旦诊断成立,及早干预可改善预后。

The Advance in the Study of the Periventricular Leukomalacia

Periventricular leukomalacia(PVL)is the main neuropathologic lesion of brain injury of premature,which closely correlates with the neurobehavioral dysfunction in the long term.The etiology of PVL is complicated,which includes anatomy,physiology,cytology and biology,et al.The pathogenesy of PVL remains unknown,free radical,exitotoxicity,infection and cytokine involved in.PVL lacks specific symptoms and the diagnosis of PVL depends on imageology.By now,PVL is short of specific treatment,and once the diagnosis of PVL is established,early intervention must be performed,which could improve the insults.