肺癌患者血清肿瘤标志物联合检测的临床意义

目的探讨肿瘤标志物癌胚抗原(CEA)、糖类抗原153(CA153)、糖类抗原199(CA199)及铁蛋白(SF)单项及联合检测对肺癌诊断的价值。方法对70例肺癌患者、68例良性肺疾病患者及62例健康对照组进行CEA、CA153、CA199及SF的检测,并计算上述指标单项及联合检测在肺癌诊断中的敏感度和特异度。结果肺癌组CEA、CA153及CA199水平明显高于良性肺病组及健康对照组(P<0.05)。4项标记物在不同病理类型肺癌中CEA、CA153及CA199总体比较均有差异,其中肺腺癌CEA及CA153水平高于其他类型(P<0.05),小细胞肺癌CA199水平高于其他类型(P<0.05)。4项肿瘤标记物联合检测的敏感度(87.7%)明显高于单项敏感度(分别为62.3%、56.1%、57.3%和62.4%)。结论CEA、CA153、CA199及SF联合检测可明显提高肺癌的检出率,联合检测对于鉴别肺癌与肺部良性疾病、肺癌不同病理分型有一定的参考价值。

Clinical significance of combined detection serum tumor markers in patients with lung cancer

Objective To study the clinical significance of single or combination detection serum tumor markers CEA,CA153 ,CA199 and SF in patients with lung cancer. Methods The CEA,CA153 ,CA199 and SF were assayed in 70 patients with lung cancer,68 patients with benign lung disease and 62 cases of normal control. The sensitivities and specificities of different tumor markers and the combined for the diagnosis of lung cancer were evaluated and compared. Results The levels of serum CEA,CA153,CA199 and SF in lung cancer patients were significantly higher than that in benign lung disease patients and normal controls（ P 〈 0.05）. The lexel of CEA and CA153 in ad- enoearcinoma were significantly higher than that of other pathology types（ P 〈 0.05 ） , and the level of CA 199 in small cell lung cancer was significantly higher than that of other pathology types（ P 〈 0.05）. The sensitivity of combination detection（87.7% ）were significantly higher than that of single item（62.3% ,56.1% ,57.3% and 62.4% ,respectively）. Conclusion The combined detection of CEA, CA153, CA199 and SF could increase the diagnostic sensitivity of lung cancer, it was proved to be as useful reference for differentiation of the lung cancer and benign lung diseases, even for different pathology types.