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Colocalization of angiotensinogen and glial fibrillary acidic protein in astrocytes in rat brain
Authors:Christian F. Deschepper   Jacob Bouhnik  William F. Ganong
Affiliation:1. Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, USA;2. Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA;1. Dubowitz Neuromuscular Centre, UCL Institute of Child Health & Great Ormond Street Hospital for Children, 30 Guilford Street, London WC1N 1EH, United Kingdom;2. Genetics Department, Institut de Génétique et Pathologie, Gosselies, Belgium;3. MRC Centre for Neuromuscular Diseases and Department of Molecular Neuroscience, University College London Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom;4. West of Scotland Regional Genetic Service, Queen Elizabeth University Hospital, Glasgow, United Kingdom;5. Institute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow, United Kingdom;6. Wolfson Centre for Inherited Neuromuscular Diseases, RJAH Orthopaedic Hospital, Oswestry, United Kingdom;7. Department of Paediatric Neurology, Neuromuscular Service, Evelina''s Children Hospital, Guy''s & St. Thomas'' Hospital NHS Foundation Trust, London, United Kingdom;8. Department of Basic and Clinical Neuroscience, IoPPN, King''s College London, London, United Kingdom;9. Randall Division of Cell and Molecular Biophysics, Muscle Signalling Section, King''s College London, London, United Kingdom;10. Department of Clinical Neurophysiology, Great Ormond Street Hospital, London, United Kingdom;11. Department of Pediatrics, University Hospital Cologne, and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany;12. Laboratory Medicine, Queen Elizabeth University Hospital and Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, United Kingdom;13. Genetics Department, Molecular Genetics Laboratory Viapath, Guy''s Hospital, London, United Kingdom;14. NIHR Great Ormond Street Hospital Biomedical Research Centre, London, United Kingdom
Abstract:Angiotensinogen is produced in the brain, but its precise localization and the cells in the central nervous system producing it are unknown. We have performed a double staining test for angiotensinogen and glial fibrillary acidic protein in rat brain and report here that these proteins colocalize in astrocytes.
Keywords:angiotensinogen   glial fibrillary acidic protein   immunocytochemistry   rat brain   astrocyte
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