三联法治疗慢性功能性便秘的疗效观察

为观察莫沙必利联合聚乙二醇4000散剂和酪酸梭菌活菌片口服（三联法）治疗慢性功能性便秘的f临床疗效，选择120例根据罗马Ⅲ标准确诊的慢性功能性便秘患者进行随机对照研究，分为治疗组和对照组，每组60例。治疗组采用三联疗法，即莫沙必利5rag／次，3次／d，口服；聚乙二醇4000散剂10g／次，2次／d，口服；酪酸梭菌活菌片2片／次，3次／d，口服。对照组单纯口服聚乙二醇4000散剂10g／次，2次／d。两组均以4剧为一疗程。观察两组总疗效及患者腹痛腹胀、排便频率、粪便性状等症状的缓解情况。结果显示．1个疗程后，治疗组总有效率明显高于对照组（93．3％vs76．7％，P〈0．05）；治疗组腹痛腹胀缓解率（P〈0．01）、排便频率及粪便性状改善率（P〈0．05）均明显高于对照组。结果表明，三联法治疗慢性功能性便秘效果优于单纯口服聚乙二醇4000散剂。

Observation on the Therapeutic Effect of Triplet Therapy for Chronic Functional Constipation

In order to investigate the clinical effect of the triplet therapy（Mosapride＋Polyethylene glycol 4000 powder ＋ Clostridium butyricum tablet） orally in the treatment of chronic functional constipation, authors selected the 120 patients who were confirmed according to Roma Ⅲ standard to perform random control study,each group 60 cases：treatment group received the triplet therapy（i, e,Mosapride,Smg/time,3 times/day,orally; Polyethylene glycol 4000 powder, 10g/time, 2 times/day, orally; Clostridium butyricum tablet, 2 tablets/time, 3 times/day, orally）, while controlled group alone took Polyethylene glycol 4000 powder,10g/time,2 times/day; the treatment course of both groups was all for 4 weeks. Then,ihe total therapeutic effect of both groups and relief status of abdominal pain, abdominal distension, defecation frequency and feces form, etc in patients were observed and recorded. As results,after one treatment course in treatment group the total effective rate （93.3% vs 76.7%, P 〈0. 05） ,the relief rate of abdominal pain and distension（ P 〈0.01）, and the improvement rate of defecation and feces form（ P 〈0.05） were all significartly higher than that in controlled group respectively. Results show that the efficacy of triplet therapy is superior to that of alone oral administration of polyethylene glycol 4000 powder in the treatment ofchronic functional constipation.