Interferon-related mental deterioration after craniotomy for removal of metastatic renal cancer |
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Authors: | SATORU TAKAHASHI HIROSHI YOKOYAMA YOSHIAKI YANAI MASASHI KURIMOTO NOBUTAKA OHTA TADAICHI KITAMURA |
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Institution: | Department of Urology, Faculty of Medicine, Tokyo University, Tokyo, Japan. takahashi-uro@h.u-tokyo.ac.jp |
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Abstract: | Interferon-related severe adverse events on the central nervous system are relatively rare, because interferon-alpha (INF-alpha) can not cross an intact blood-brain barrier. We experienced remarkable mental deterioration caused by INF-alpha administration in a 43-year-old man with renal cell carcinoma after surgical removal of a metastatic brain tumor. We detected a high concentration of INF-alpha in a cerebrospinal fluid sample, which was comparable to that in the serum at 24 h after the administration of INF-alpha; 5x10(6) IU i.m., suggesting that the blood-brain barrier was damaged somehow by the craniotomy. The mental deterioration improved shortly after discontinuation of the INF-alpha administration. |
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Keywords: | craniotomy interferon α mental deterioration renal cell carcinoma |
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