西藏高原红细胞增多症发病率及其血红蛋白特异性研究

在西藏两个不同海拔高度地区世居和移居人群中进行高原红细胞增多症(HAPC)调查及对其血红蛋白(Hb)特异性进行研究。结果表明:(1)西藏拉萨地区人群中HAPC总发病率为2.39％,那曲-安多地区为12.95％,随海拔升高而发病率增多,汉族的发病率高于藏族,男性高于女性;(2)HAPC患者红细胞中MetHb为10.14％,显著高于高原健康人红细胞中的MetHb含量(6.35％),这可能是HAPC患者血液携带氧功能降低原因之一;(3)HAPC患者红细胞的穆斯堡尔谱除正常oxy-Hb和deoxy-Hb组分外,还发现存在第三组分“c”,这可能是血红蛋白的变性产物,是否与红细胞携带氧有关尚待研究。

Investigation on the Incidence of High Altitude Polycythemia and Its Hemoglobin Characteristics in a Tibetan Population

The incidences of high altitude polycythemia (HAPC) and its hemoglobin characteristics in natives and immigrants at 2 different altitudes in the Tibet Autonomous Region were investigated. The results were as follows: 1) The incidences of HAPC among residents in Lhasa (3650 meters above sea level) and in Naqu-Ando district (4500-4800 meters above sea-level) were 2.39% and 12.95%, respectively. The incidence of HAPC increased with increasing altitude. The incidences in immigrants and in men were higher than those in natives and in women. 2) The MetHb concentration in RBC from patients with HAPC was 10.14%, distinctly higher than that in healthy adults (6.35%) in the same area. This may he one of the causes leading to oxygen carrying malfunction in the RBCs of HAPC patients. 3) The Mossbauer spectra of RBCs from patients with HAPC had a third component "c" in addition to the two normal components, oxy-Hb "a" and deoxy-Hb "b." The third component "c" may be adenatured Hb in the RBCs of the patients. The question of whether it is related to oxygen carrying power requires further study.