血管内皮生长因子在重度子癎痫前期产妇新生儿脐血中的表达

目的 探讨血管内皮生长因子(VEGF)在重度子癎前期产妇分娩的新生儿脐静脉血、脐动脉血中的表达及其意义.方法 采用放射免疫分析法检测26例重度子癎前期产妇所分娩新生儿(重度子癎前期组)与30例健康产妇所分娩新生儿(对照组)的脐静脉血、脐动脉血VEGF水平.重度子癎前期组新生儿按照其出生体质量-胎龄分类分为小于胎龄儿15例(SGA组)和适于胎龄儿11例(AGA组).结果 (1)重度子癎前期组脐静脉血、脐动脉血VEGF水平(15.26±5.28)pg/ml、(19.334±4.45)pg/ml]均显著高于对照组(12.78±3.21)pg/ml、(14.55±2.90)pg/ml](t=2.16,P<0.05;t=4.82,P<0.01).(2)对照组和重度子癎前期组的脐动脉血VEGF水平均显著高于脐静脉血VEGF水平(t=2.24,P<0.05;t=3.00,P<0.01).(3)对照组和重度子癎前期组脐静脉血和脐动脉血VEGF水平与新生儿胎龄或出生体质量均无明显相关性.(4)重度子癎前期SGA组的脐动脉血VEGF水平(21.38±3.68pg/ml)显著高于AGA组(16.53±3.96pg/ml)和对照组(t=3.22,P<0.01;t=6.80,P<0.01).结论 重度子癎前期产妇新生儿脐静脉血和脐动脉血VEGF水平均较健康产妇新生儿明显升高;脐动脉血VEGF水平在一定程度上可反映妊娠期高血压疾病产妇的新生儿宫内损伤程度.

Expression of vascular endothelial growth factor in serum of umbilical blood from the newborns of women with severe pre-eclampsia

Objective To study the expression and significance of vascular endothelial growth factor(VEGF) in serum of umbilical blood from the newborns of women with severe pre-eclampsia.Methods Radioimmunoassay was used to measure the serum VEGF of umbilical blood from 26 newborns of women with severe pre-eclampsia (severe pre-eclmpsia group) and 30 newborns of normal pregnancy women (control group). According to birth weight-gestational age relation,severe pre-eclampsia group included 15 newborns small for gestational age (SGA group) and 11 newborns appropriate for gestational age (AGA group).Results (1)The VEGF level of umbilical vein blood and umbilical artery blood in severe pre-eclmpsia group was significantly higher than that in control group respectively(t = 2.16, P < 0.05;t = 4.82, P < 0.01). (2) In control group and severe pre-eclampsia group, the VEGF level in umbilical artery blood was significantly higher than that in umbilical vein blood (control group: t = 2.24, P < 0.05;severe pre-eclampsia group: t = 3.00, P < 0.01). (3)In both control group and severe pre-eclampsia group, there was no significant correlation respectively between VEGF levels in umbilical vein blood or umbilical artery blood and newborns' gestational age or birth weight. (4)VEGF level of umbilical artery blood in SGA group was significantly higher than that in AGA group as well as in control group(t = 3.22, P < 0.01 ;t = 6.80, P < 0.01). Conclusions The serum VEGF level of umbilical vein blood and umbilical artery blood from the newborns of women with severe pre-eclampsia was significantly higher than that of normal pregnancy women respectively. The VEGF level of umbilical artery blood can reflect the severity degree of the damage of hypertensive disorder complicating pregnancy to their newborns to some degree.