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| 七氟烷对小鼠学习记忆的影响 | |
| 引用本文： | 陈银宝,徐小林,徐 佳,周 艳,蒋 齐,戴体俊. 七氟烷对小鼠学习记忆的影响[J]. 药学与临床研究, 2010, 18(5): 429-431 |
| 作者姓名： | 陈银宝 徐小林 徐 佳 周 艳 蒋 齐 戴体俊 |
| 作者单位： | 1. 徐州医学院,公共卫生学院,徐州,221002 2. 徐州医学院,临床二系,徐州,221002 3. 徐州医学院,影像学院,徐州,221002 4. 徐州医学院,麻醉药理学教研室,徐州,221002 |
| 基金项目： | 国家自然科学基金资助项目，江苏省自然科学基金资助项目 |
| 摘 要： | 目的:观察腹腔注射七氟烷对小鼠学习记忆的影响.方法:小鼠随机分为4组(n=10):生理盐水组(NS组,ip)、七氟烷0.5 mL/kg、1.0 mL/kg、2.0 mL/kg剂量组分别用跳台法、避暗法的跳台潜伏期、步入潜伏期及错误次数,以及Y迷宫法10次测试中一次性正确次数作为评估小鼠学习记忆成绩的指标.结果:3种方法观察各组间小鼠的学习记忆成绩均无明显差异(P>0.05).结论:在本实验条件下,七氟烷对小鼠的学习记忆无明显影响. |
| 关 键 词： | 七氟烷 跳台实验 避暗实验 Y迷宫实验 学习记忆 |
| 收稿时间： | 2010-01-06 |
| 修稿时间： | 2010-05-17 |
Effects of Sevoflurane on Learning and Memory in Mice |
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| CHEN Yin-bao,XU Xiao-lin,XU Ji,ZHOU Yan,JIANG Qi and DAI Ti-jun. Effects of Sevoflurane on Learning and Memory in Mice[J]. Pharmacertical and Clinical Research, 2010, 18(5): 429-431 | |
| Authors: | CHEN Yin-bao XU Xiao-lin XU Ji ZHOU Yan JIANG Qi DAI Ti-jun |
| Affiliation: | Department of Public Health, Xuzhou Medical College, Xuzhou 221002, China;Department of Public Health, Xuzhou Medical College, Xuzhou 221002, China;Second Clinical Department, Xuzhou Medical College, Xuzhou 221002, China;Department of Public Health, Xuzhou Medical College, Xuzhou 221002, China;Department of Medical Imaging, Xuzhou Medical College, Xuzhou 221002, China;Department of Anesthetic Pharmacology, Xuzhou Medical College, Xuzhou 221002, China |
| Abstract: | Objective: To observe the effects of sevoflurane on learning and memory in mice. Methods: Forty mice were randomly divided into 4 groups (group NS, Sev1, Sev2 and Sev3, ip). The mice were evaluated by step-down test, step-through test and Y-electrical maze test with latency, error times and correct rates recorded as indexes. Results: NO statistical significance was noted in learning and memory indexes of each group. Conclusion: Sevoflurane has no significant influence on learning and memory in mice. |
| Keywords: | Sevoflurane Step-down test Step-through test Y-electrical maze test Earning and memory |
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