肺癌组织中CD44v6和nm23H1的mRNA表达及临床意义

目的：探讨CD44v6和nm23H1的mRNA表达与肺癌临床意义及其相关性。方法：应用原位杂交CSA方法，检测65例肺癌组织CD44v6和nm23H1的mRNA表达，结合临床病理指标及随访病例进行研究分析。结果：在肺癌中CD44v6和nm23H1的mRNA表达阳性率分别为66.2%和49.2%。CD－44v6mRNA高表达和nm23H1mRNA低表达均与肺癌PTNM分期、病理分级和淋巴结转移呈正相关，患者＞5年存活率越低。肺癌CD44v6mRNA表达与nm23H1mRNA表达呈负相关。结论：肺癌中CD－44v6mRNA表达与nm23H1mRNA表达具有负调节的协同作用，均可作为预测肺癌转移和评估预后的重要生物学指标。

Expression of CD44v6 and nm23H1 mRNA and Their Clinical Significance in Human Iung Carcinoma

Objective:To investigate the expres sion of CD44v6 and nm23H1 mRNA,and the clinical significance and correlativity i n primary lung carcinoma.Methods CSA hydridization method was applied to test th e expression of CD44v6 and nm23H1 mRNA of lung carcinoma in 65 cases,which were studied and analyzed with their clinicopathologe features and follow-up cases.Re sults:The positive expression of CD44v6 and nm23H1 mRNA in lung carcinoma was 66 .2% and 49.2% respectively.Overexpression of CD44v6 mRNA and low expression of n m23H1 mRNA were positively correlated with PTNM stages,Pathologic grades and lym ph node metastasis in lung carcinoma.The patients of that were poor prognosticat ed five-year surviral rate.The expression of CD44v6 mRNA Showed paradoxical rela tionship with that of nm23H1 mRNA.Conclusions:The expression between CD44v6 and nm23H1 mRNA showed coordination of ngative correlation,which may serve as an imp ortant biological indicator of metastasis and prognosis of lung carcinoma.