Immunological Defects in a Bis(dichloroacetyl) diamine Induced Malformation Complex in Rats Closely Resembling the DiGeorge Syndrome |
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| Authors: | Takahiro OKISHIMA Yoshito EIZURU Yoichi MINAMISHIMA Shozo OHDO Kunio HAYAKAWA |
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| Institution: | Department of Pediatrics, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki, 889–16 Japan;*Department of Microbiology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki, 889–16 Japan |
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| Abstract: | ABSTRACT: Spleen cells from newborn rats with bisdiamine-induced congenital malformation were examined for subpopulation of lymphocytes and responsiveness of the lymphocytes to phytohemagglutinin (PHA), concanavalin A (ConA) and lipopolysaccharide (LPS). T cells, but not B cells, were significantly diminished in the drug-treated newborn rats. Proliferative response of the lymphocytes to PHA and ConA, but not to LPS, was significantly depressed in the drug-treated newborns. Thus a defect in cell-mediated immunity was suggested to be associated with the congenital anomaly.
It is tempting to consider that this bisdiamine-induced malformation can be another animal model for the DiGeorge syndrome. |
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| Keywords: | bisdiamine malformation immunological defect |
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