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甘氨酰谷氨酰胺二肽改善猪自体移植小肠的吸收功能
引用本文:蒋建文,黎介寿,李幼生,王新波,汪志明,刘放南.甘氨酰谷氨酰胺二肽改善猪自体移植小肠的吸收功能[J].肠外与肠内营养,2000,7(2):80-82.
作者姓名:蒋建文  黎介寿  李幼生  王新波  汪志明  刘放南
作者单位:1. 第二军医大学,上海,200433
2. 南京军区南京总医院解放军普通外科研究所,江苏南京,210002
摘    要:目的:观察甘氨酰谷氨酰胺二肽对猪自体移植小肠吸收功能的作用。方法:杂种猪10只,行自体小肠移植,术后随机分为两组,标准TPN组(STPN组,n=5),接受标准TPN支持8天;Gly-Gln二肽组(GTPN组,n=5),接受含Gly-Gln的TPN支持8天,术后1天(POD1)及术后28天(POD28)行木糖吸收实验,测定肠粘膜酶活性。结果:术后28天,GTPN组:木糖吸收曲线下面积,5h尿液木糖排

关 键 词:小肠移植  谷氨酰胺  肠粘膜  吸收功能
文章编号:1007-810X(2000)02-0080-02
修稿时间:1999-12-21

The dipeptide glycyl-glutamine enhances absorptive function of autotransplanted small intestine in pig
JIANG Jian-wen,LI Jie-shou,LI You-sheng,WANG Xin-bo,WANG Zhi-ming,LIU Fang-nan.The dipeptide glycyl-glutamine enhances absorptive function of autotransplanted small intestine in pig[J].Parenteral & Enteral Nutrition,2000,7(2):80-82.
Authors:JIANG Jian-wen  LI Jie-shou  LI You-sheng  WANG Xin-bo  WANG Zhi-ming  LIU Fang-nan
Abstract:Objectives:To observe the impact of glycyl- glutamine( Gly- Gln) dipeptide on the ab- sorptive function of autotransplated small bowel in pig. Methods:Ten unbred pigs underwentsmall bowel autotransplantation and were divided randomly into two groups:GTPN and STPN.In GTPN group( n=5) ,the pigs received TPN supplemented with3% Gly- Gln for2 8dyas,while in STPN group( n=5) ,the pigs received isonitrogenous and isocaloric standard TPN for2 8dyas.D- xylose absorption testand the activity of disaccharidase were measured on the1 stand2 8th post- operative day. Results:The D- xylose absorption and the activity of disaccharidase in GTPN group were significantly higher than those in STPN group( P<0 .0 5) on the 2 8th postoperative day. Conclusions:Gly- Gln can improve the absorptive function of autotransplanted small intes- tine in pig.
Keywords:Organ transplantation  Small intestine  Glutamine  Mucosa  Absorptive  function
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